{"id":"W3134147795","doi":"10.1002/wsbm.1519","title":"Lineage‐instructive functions of the <scp>E26</scp>‐transformation‐specific‐family transcription factor <scp>Spi‐C</scp> in immune cell development and disease","year":2021,"lang":"en","type":"review","venue":"WIREs Mechanisms of Disease","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Transcription factor; Biology; Cell biology; Cellular differentiation; B cell; Epigenetics; Cell fate determination; Myeloid; Cell; Genetics; Immunology; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005242132,0.0007835747,0.0007744313,0.001775367,0.0002451576,0.0007565622,0.0007191878,0.0009871117,0.002360536],"category_scores_gemma":[0.0004475696,0.0002238693,0.0002773156,0.001981341,0.0005985076,0.001130734,0.0007557048,0.001564392,0.002280446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006734485,"about_ca_system_score_gemma":0.0007614219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006571772,"about_ca_topic_score_gemma":0.000971162,"domain_scores_codex":[0.9998728,0.00002069581,0.00001835402,0.00002671773,0.00004518709,0.00001629488],"domain_scores_gemma":[0.9997923,0.00009133934,0.00002524524,0.000008394635,0.00005227359,0.00003041051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005103608,0.00003827438,0.000138262,0.005967915,0.00003142246,0.0001875597,0.00005383257,0.000400749,0.003389642,0.00579121,0.02603268,0.9579175],"study_design_scores_gemma":[0.000006772192,0.00005138432,0.0005956045,0.001159017,0.00003512089,0.001180413,0.0000329299,0.00007394171,0.000937258,0.001667666,0.9942463,0.00001361557],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001240821,0.9977733,0.0002579046,0.0002614052,0.0002309125,0.000003438683,0.00001651695,0.00001264206,0.00131976],"genre_scores_gemma":[0.0007524253,0.9978308,0.0002395788,0.0001621429,0.0002059371,0.00000625097,0.00002931066,0.000002619456,0.0007709299],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002360536,"threshold_uncertainty_score":0.007896721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145934612373868,"score_gpt":0.2483155766602276,"score_spread":0.2268562305364889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}