{"id":"W3134147795","doi":"10.1002/wsbm.1519","title":"Lineage‐instructive functions of the <scp>E26</scp>‐transformation‐specific‐family transcription factor <scp>Spi‐C</scp> in immune cell development and disease","year":2021,"lang":"en","type":"review","venue":"WIREs Mechanisms of Disease","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Transcription factor; Biology; Cell biology; Cellular differentiation; B cell; Epigenetics; Cell fate determination; Myeloid; Cell; Genetics; Immunology; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002129545,0.0004577501,0.0007591608,0.0001750218,0.0001261822,0.00003614777,0.0003107402,0.0002884381,0.000005027474],"category_scores_gemma":[0.0002002963,0.0003834931,0.0005395013,0.0002678954,0.0001043723,0.00001825422,0.0001220567,0.0002132446,0.000002683997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004845211,"about_ca_system_score_gemma":0.0008173226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007615069,"about_ca_topic_score_gemma":0.00001177051,"domain_scores_codex":[0.9975272,0.0002590424,0.000993821,0.0005504439,0.0003781396,0.000291303],"domain_scores_gemma":[0.9982917,0.0000785695,0.0005383519,0.0005876,0.0001985478,0.0003052479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001073859,0.002466999,0.0002782155,0.03983573,0.001283048,0.00002910684,0.00309957,0.0005168376,0.3394445,0.004611337,0.0004219304,0.6079054],"study_design_scores_gemma":[0.001722854,0.0002473631,0.004182598,0.005237741,0.001471979,0.000001533964,0.001194918,0.00004871928,0.2760381,0.000979692,0.7085004,0.0003742024],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0627307,0.9242499,0.01025379,0.000008014169,0.0004454383,0.001056128,0.001037795,0.00001040169,0.0002078276],"genre_scores_gemma":[0.08364851,0.9127305,0.0009487341,0.00002046372,0.00009072999,0.0001836286,0.001715525,0.00007408013,0.0005878501],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7080784,"threshold_uncertainty_score":0.9998617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145934612373868,"score_gpt":0.2483155766602276,"score_spread":0.2268562305364889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}