{"id":"W3134155656","doi":"10.1093/jcag/gwab002.147","title":"A149 <i>TRP53</i> LOSS IN <i>KRT15+</i> INTESTINAL STEM CELLS SEVERELY AFFECTS SECRETORY CELL FATE AND SELF-RENEWAL","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"LGR5; Stem cell; Biology; Intestinal epithelium; Cell biology; Multipotent Stem Cell; Progenitor cell; Wnt signaling pathway; Adult stem cell; Cancer stem cell; Cancer research; Cellular differentiation; Immunology; Epithelium; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535617,0.0003310406,0.0003074053,0.0003028657,0.0001348542,0.0003167726,0.0002812138,0.0004559137,0.003397303],"category_scores_gemma":[0.0001127689,0.0001764175,0.0003933274,0.0001509953,0.0003291584,0.0002359486,0.000187371,0.000929892,0.0008566771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002015976,"about_ca_system_score_gemma":0.0001537971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007945456,"about_ca_topic_score_gemma":0.0006877453,"domain_scores_codex":[0.9997237,0.00002906851,0.00005803126,0.00006482856,0.00006074546,0.00006351358],"domain_scores_gemma":[0.9996911,0.00004077587,0.0001044326,0.00003875918,0.00001933308,0.0001056968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008726442,0.0000284839,0.0001754476,0.00001934519,0.000004922099,0.00006568502,0.00001129971,0.00003768824,0.9989473,0.0000600758,0.00005159302,0.0005109755],"study_design_scores_gemma":[0.00001963566,0.0003662116,0.005536905,0.000008194575,0.00002003623,0.0005118266,0.00005538124,0.0007462762,0.9901535,0.00004107421,0.002534659,0.000006349917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930643,0.0006809038,0.002483744,0.0001551638,0.00005893819,0.00004824076,0.001525811,0.0002037289,0.001779192],"genre_scores_gemma":[0.9923995,0.00034628,0.001305518,0.00008930798,0.000008580367,0.00005227398,0.001298822,0.00006275564,0.004436905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003397303,"threshold_uncertainty_score":0.01136518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004538493950657326,"score_gpt":0.2056198554307015,"score_spread":0.2010813614800442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}