{"id":"W3134156560","doi":"10.1007/s11883-021-00914-7","title":"ANGPTL3 and Apolipoprotein C-III as Novel Lipid-Lowering Targets","year":2021,"lang":"en","type":"review","venue":"Current Atherosclerosis Reports","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bausch Health; Servier; Mylan; Eli Lilly and Company","keywords":"Apolipoprotein B; Medicine; PCSK9; Lipolysis; Internal medicine; Endocrinology; Triglyceride; Cholesterol; Pharmacology; Lipoprotein; Adipose tissue; LDL receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000521987,0.001005974,0.003679925,0.0003053196,0.0001847753,0.0001513148,0.0001594287,0.0005240057,0.0003283614],"category_scores_gemma":[0.0005248475,0.0008312021,0.00110868,0.0005688242,0.0001712447,0.0001644719,0.0003821638,0.0008321161,0.00004864102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126866,"about_ca_system_score_gemma":0.0008152189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00012125,"about_ca_topic_score_gemma":0.000004309831,"domain_scores_codex":[0.9953196,0.00007142413,0.001623039,0.001495521,0.0007334226,0.0007570141],"domain_scores_gemma":[0.9966974,0.0000696811,0.001050516,0.00138142,0.0001820724,0.0006189664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005587586,0.0004972807,0.0001215774,0.01323282,0.0002600702,0.00006180489,0.000203481,1.269745e-7,0.0001414334,0.00006365004,0.002249784,0.9831624],"study_design_scores_gemma":[0.0006751676,0.00005491923,0.0001552946,0.0288015,0.001940643,0.0008828912,0.00003320053,9.917105e-7,0.00004992493,0.0000119839,0.9666636,0.0007298717],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007230035,0.9917533,0.00009260167,0.00003538843,0.004373977,0.001957493,0.00003555276,0.000190329,0.0008382978],"genre_scores_gemma":[0.0001920698,0.9958369,0.0002346187,0.00008211313,0.00168176,0.0004395041,0.000478168,0.0002141638,0.0008407201],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9824325,"threshold_uncertainty_score":0.9994139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07011669680821178,"score_gpt":0.3552587299497029,"score_spread":0.2851420331414911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}