{"id":"W3134156560","doi":"10.1007/s11883-021-00914-7","title":"ANGPTL3 and Apolipoprotein C-III as Novel Lipid-Lowering Targets","year":2021,"lang":"en","type":"review","venue":"Current Atherosclerosis Reports","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bausch Health; Servier; Mylan; Eli Lilly and Company","keywords":"Apolipoprotein B; Medicine; PCSK9; Lipolysis; Internal medicine; Endocrinology; Triglyceride; Cholesterol; Pharmacology; Lipoprotein; Adipose tissue; LDL receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005460295,0.0009072341,0.001373644,0.001331119,0.0001547526,0.001070961,0.000684187,0.0009272679,0.002734195],"category_scores_gemma":[0.0006332905,0.0002374342,0.0004138261,0.001512673,0.0003105267,0.0009763202,0.0005463718,0.002094623,0.001487352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003851264,"about_ca_system_score_gemma":0.0007784642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006320375,"about_ca_topic_score_gemma":0.001463014,"domain_scores_codex":[0.9998707,0.00002142904,0.00002057019,0.0000206081,0.00004967404,0.00001696944],"domain_scores_gemma":[0.9998193,0.00007413887,0.00003662497,0.000005300024,0.00004029604,0.00002432797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003314341,0.0001086622,0.0002192458,0.01014771,0.0001688724,0.0002992394,0.00003056141,0.0003631257,0.002477323,0.002357212,0.03143805,0.9520586],"study_design_scores_gemma":[0.000185611,0.0002670776,0.00142873,0.003102014,0.0004802649,0.001377488,0.00004882769,0.0003225262,0.001136913,0.002640622,0.9889745,0.00003552496],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001598628,0.998643,0.0001144035,0.0002406661,0.0002595364,0.000003267857,0.00002162082,0.000006867817,0.0005508856],"genre_scores_gemma":[0.0009019714,0.9976254,0.0001987823,0.0003118576,0.0003791775,0.000006068334,0.00005219578,0.000001678381,0.0005229306],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002734195,"threshold_uncertainty_score":0.00914675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07011669680821178,"score_gpt":0.3552587299497029,"score_spread":0.2851420331414911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}