{"id":"W3134168476","doi":"10.1016/j.ygyno.2021.02.038","title":"Chromosome instability is prevalent and dynamic in high-grade serous ovarian cancer patient samples","year":2021,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Strong; CancerCare Manitoba Foundation; Diagnostic Services Manitoba; Cancer Research Society","keywords":"Serous fluid; Chromosome instability; Medicine; Ascites; Malignancy; Aneuploidy; Ovarian cancer; Disease; Cancer; Genome instability; Cancer research; Oncology; Internal medicine; Pathology; Chromosome; Biology; Genetics; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781271,0.0002127569,0.0003641671,0.00004498312,0.00007659305,0.00001602018,0.0001456392,0.0004554341,0.0002941962],"category_scores_gemma":[0.0001677085,0.000204515,0.00006849801,0.0001288009,0.0001497871,0.000005287347,0.0003445187,0.0001965423,0.000005643693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002666954,"about_ca_system_score_gemma":0.0004360912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002688273,"about_ca_topic_score_gemma":0.01067844,"domain_scores_codex":[0.9981805,0.0002684398,0.0003627267,0.0006949464,0.00008061043,0.0004127411],"domain_scores_gemma":[0.9992405,0.00007441941,0.0001223284,0.0003803198,0.00008608108,0.00009641773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001526885,0.001676181,0.1375312,0.0001784797,0.0001873461,0.000204196,0.0007289293,0.0002360616,0.7675042,0.0003454599,0.001175154,0.09008016],"study_design_scores_gemma":[0.005047346,0.003454327,0.6799386,0.0000476591,0.0001391775,0.0002519633,0.0009553066,0.0004503566,0.1156283,0.002302869,0.1907126,0.001071488],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940462,0.003016795,0.00008325616,0.001643702,0.0004248618,0.0003702762,0.000153881,0.00001507651,0.0002459152],"genre_scores_gemma":[0.9910984,0.004552506,0.001572855,0.002175554,0.00005192262,0.0001715591,0.0001795947,0.00001732607,0.0001802956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6518759,"threshold_uncertainty_score":0.8339881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330403201241495,"score_gpt":0.2745615524562043,"score_spread":0.2612575204437893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}