{"id":"W3134169755","doi":"10.1016/j.esmoop.2021.100063","title":"Tucatinib approval by EMA expands options for HER2-positive locally advanced or metastatic breast cancer","year":2021,"lang":"en","type":"editorial","venue":"ESMO Open","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Metastatic breast cancer; Oncology; Medicine; Breast cancer; Cancer; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004302197,0.0005821222,0.001394274,0.00007685228,0.0002354535,0.0002215575,0.0004438413,0.0003174372,0.002141136],"category_scores_gemma":[0.0003872645,0.0004301283,0.0003383415,0.0002647417,0.0001013065,0.0001831957,0.0002713378,0.0005272144,0.00002851062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000435781,"about_ca_system_score_gemma":0.003088559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002812169,"about_ca_topic_score_gemma":0.001319765,"domain_scores_codex":[0.9970967,0.0001668662,0.0005767136,0.0009864824,0.000640879,0.0005323384],"domain_scores_gemma":[0.9969927,0.0009343569,0.0003402421,0.0006764775,0.000726537,0.0003297066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002431574,0.001158325,0.000007299476,0.0004028995,0.002088079,0.0001857199,0.0002032995,0.00001003209,0.00001358896,0.00006899322,0.9676608,0.02576936],"study_design_scores_gemma":[0.01104489,0.001422922,0.0000920238,0.001532926,0.002623724,0.00007883344,0.0006997907,0.00003297544,0.0002684614,0.00005550079,0.9816238,0.0005241837],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0004340018,0.005889658,0.005139788,0.01106596,0.8668877,0.01931234,0.08777659,0.0001617335,0.003332261],"genre_scores_gemma":[0.0007873709,0.003393678,0.08249243,0.001577402,0.6515841,0.02293128,0.0887828,0.0005965682,0.1478543],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.2153035,"threshold_uncertainty_score":0.999815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02494866263595423,"score_gpt":0.3808935649606516,"score_spread":0.3559449023246973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}