{"id":"W3134172846","doi":"10.1186/s13063-021-05164-1","title":"A novel preference-informed complementary trial (PICT) design for clinical trial research influenced by strong patient preferences","year":2021,"lang":"en","type":"article","venue":"Trials","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; Hospital for Sick Children; University of Toronto; Children’s Health Research Institute; Institute of Health Economics; Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Centre hospitalier universitaire Sainte-Justine; Children's Health Research Institute; Women and Children's Health Research Institute; Research Manitoba; Alberta Children's Hospital Research Institute; CHEO Research Institute; Kidscan Children's Cancer Research","keywords":"External validity; Preference; Internal validity; Research design; Clinical study design; Randomized controlled trial; Clinical trial; Medicine; Psychological intervention; Population; Sample size determination; Comparative effectiveness research; Alternative medicine; Psychology; Applied psychology; Management science; Computer science; Social psychology; Psychiatry; Surgery; Engineering; Statistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.1931293,0.003199437,0.004086853,0.00277809,0.001659118,0.004060898,0.003318521,0.008211344,0.020508],"category_scores_gemma":[0.2695372,0.001922842,0.005210191,0.002866934,0.005817287,0.005792324,0.004860776,0.006278822,0.002669326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00259578,"about_ca_system_score_gemma":0.007026924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004111471,"about_ca_topic_score_gemma":0.0005891481,"domain_scores_codex":[0.59072,0.3786903,0.01146504,0.007834542,0.009690653,0.001599386],"domain_scores_gemma":[0.7204205,0.2227558,0.01886507,0.02487267,0.00918893,0.003897024],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.1211033,0.005458293,0.01002107,0.03070503,0.009173611,0.001772236,0.005334131,0.04055681,0.005920417,0.3659901,0.01747689,0.3864882],"study_design_scores_gemma":[0.1884567,0.06097122,0.007702154,0.006487231,0.009689529,0.002136281,0.0008736274,0.1995267,0.006364166,0.4422967,0.07448439,0.001011237],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.02076537,0.002799279,0.82283,0.005398707,0.002855079,0.1330448,0.001253678,0.0008540566,0.0101991],"genre_scores_gemma":[0.1340291,0.000778158,0.5915843,0.004690974,0.0006411395,0.2663587,0.0003010625,0.00005781602,0.00155873],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.8068707,"threshold_uncertainty_score":0.9950153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9740774375883522,"score_gpt":0.7368860082694295,"score_spread":0.2371914293189227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}