{"id":"W3134179115","doi":"10.1038/s41587-021-00836-4","title":"Affinity-matured HLA class II dimers for robust staining of antigen-specific CD4+ T cells","year":2021,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Government of Canada; Ontario Institute for Cancer Research; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Uehara Memorial Foundation","keywords":"Human leukocyte antigen; Antigen; T-cell receptor; Epitope; Major histocompatibility complex; Molecular biology; Biology; Streptamer; MHC class I; T cell; Cytotoxic T cell; Immunology; In vitro; Chemistry; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003470757,0.0004917122,0.0002600374,0.0002896503,0.0003499241,0.0006785344,0.0004763303,0.000834163,0.006985193],"category_scores_gemma":[0.0003046185,0.0004710911,0.0002380237,0.0002448978,0.0001768373,0.0002969695,0.0005407868,0.001642906,0.001725684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936574,"about_ca_system_score_gemma":0.0002621563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003291204,"about_ca_topic_score_gemma":0.001078884,"domain_scores_codex":[0.9994622,0.0001355154,0.00003344466,0.000113088,0.00009918788,0.0001566555],"domain_scores_gemma":[0.9998028,0.00006782567,0.00002135657,0.00003967598,0.0000224115,0.00004598585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003884585,0.00001490714,0.00003432368,0.00001644133,0.00000239599,0.00001288762,0.000007931294,0.00005226628,0.9988928,0.000121567,0.00009716369,0.000708497],"study_design_scores_gemma":[0.00002815328,0.00009838914,0.0008516522,0.000006501162,0.000008884187,0.0002003317,0.00001723995,0.002703831,0.9923273,0.0001475824,0.00360367,0.000006472544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8985694,0.002151422,0.0882349,0.0005277884,0.0002504842,0.0002606238,0.0005767694,0.0006037574,0.00882489],"genre_scores_gemma":[0.9564748,0.0007267788,0.03337969,0.0002982607,0.00006097135,0.0002155315,0.0007431952,0.0001940693,0.007906799],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.006985193,"threshold_uncertainty_score":0.02336776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153320882127664,"score_gpt":0.2365740791899099,"score_spread":0.2250408703686332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}