{"id":"W3134181354","doi":"10.1038/s41591-020-01227-z","title":"Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics","year":2021,"lang":"en","type":"review","venue":"Nature Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":373,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Janssen Pharmaceuticals; National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institute on Aging; NIHR Cambridge Biomedical Research Centre; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Natural Science Foundation of China; National Research Foundation of Korea; Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center; Canadian Institutes of Health Research; Klarman Cell Observatory, Broad Institute; Helmholtz Artificial Intelligence Cooperation Unit; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Ministerie van Economische Zaken en Klimaat; National Institute of Diabetes and Digestive and Kidney Diseases; Knut och Alice Wallenbergs Stiftelse; UK Regenerative Medicine Platform; Vetenskapsrådet; Horizon 2020 Framework Programme; Deutsches Zentrum für Lungenforschung; Fondation pour la Recherche Médicale; Cancerfonden; British Heart Foundation; Bundesministerium für Bildung und Forschung; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; National Institutes of Health; Rosetrees Trust; National Research Foundation; Silicon Valley Community Foundation; National Institute for Health and Care Research; Manton Foundation; U.S. Department of Defense; Cancer Research UK; Wellcome Trust; Stand Up To Cancer; Cambridge University Hospitals; Entertainment Industry Foundation; LUNGevity Foundation; Imperial College London; Deutsches Zentrum für Herz-Kreislaufforschung; Bill and Melinda Gates Foundation; University of Washington; European Commission; Familjen Erling-Perssons Stiftelse; Howard Hughes Medical Institute; Conseil Départemental des Alpes Maritimes; University of Cambridge; Doris Duke Charitable Foundation; Boehringer Ingelheim; Chan Zuckerberg Initiative; Stiftelsen för Strategisk Forskning; Richard and Susan Smith Family Foundation; Heart and Stroke Foundation of Canada; National Science Foundation","keywords":"TMPRSS2; Biology; Immunology; Cell type; Proteases; Coronavirus; Tropism; Viral entry; Tissue tropism; Transcriptome; Cell; Gene expression; Virology; Virus; Gene; Pathology; Medicine; Viral replication; Genetics; Disease; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007318523,0.001134691,0.003376466,0.003800343,0.0005485357,0.002070529,0.001135732,0.001227555,0.001898609],"category_scores_gemma":[0.009893415,0.000561188,0.007317006,0.003538135,0.0003909977,0.0008119073,0.001001708,0.0008605414,0.0005024926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004972445,"about_ca_system_score_gemma":0.0006001333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002373061,"about_ca_topic_score_gemma":0.004244708,"domain_scores_codex":[0.9954029,0.001342664,0.0004948545,0.001998443,0.0005460491,0.000215022],"domain_scores_gemma":[0.9902493,0.006013427,0.0009272128,0.001577304,0.0009612815,0.000271479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002848574,0.00005736133,0.7460411,0.005256212,0.1597714,0.0008818392,0.0003634854,0.003683108,0.05135635,0.0003504459,0.002047668,0.02734253],"study_design_scores_gemma":[0.0001354305,0.0009228744,0.7933931,0.0008072375,0.1688645,0.001963826,0.0007196232,0.007359618,0.0119467,0.001323961,0.01246356,0.00009959181],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8209474,0.1110185,0.02469491,0.000499947,0.0003809854,0.0002617451,0.0391661,0.0004610794,0.002569309],"genre_scores_gemma":[0.9692445,0.00547569,0.006200496,0.0004239885,0.00009525837,0.0002136972,0.01746287,0.0002414987,0.0006421],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007318523,"threshold_uncertainty_score":0.03870451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.180615728563271,"score_gpt":0.4653066151737575,"score_spread":0.2846908866104865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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