{"id":"W3134181354","doi":"10.1038/s41591-020-01227-z","title":"Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics","year":2021,"lang":"en","type":"review","venue":"Nature Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":373,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Janssen Pharmaceuticals; National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institute on Aging; NIHR Cambridge Biomedical Research Centre; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Natural Science Foundation of China; National Research Foundation of Korea; Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center; Canadian Institutes of Health Research; Klarman Cell Observatory, Broad Institute; Helmholtz Artificial Intelligence Cooperation Unit; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Ministerie van Economische Zaken en Klimaat; National Institute of Diabetes and Digestive and Kidney Diseases; Knut och Alice Wallenbergs Stiftelse; UK Regenerative Medicine Platform; Vetenskapsrådet; Horizon 2020 Framework Programme; Deutsches Zentrum für Lungenforschung; Fondation pour la Recherche Médicale; Cancerfonden; British Heart Foundation; Bundesministerium für Bildung und Forschung; Agence Nationale de la Recherche; Deutsche Forschungsgemeinschaft; National Institutes of Health; Rosetrees Trust; National Research Foundation; Silicon Valley Community Foundation; National Institute for Health and Care Research; Manton Foundation; U.S. Department of Defense; Cancer Research UK; Wellcome Trust; Stand Up To Cancer; Cambridge University Hospitals; Entertainment Industry Foundation; LUNGevity Foundation; Imperial College London; Deutsches Zentrum für Herz-Kreislaufforschung; Bill and Melinda Gates Foundation; University of Washington; European Commission; Familjen Erling-Perssons Stiftelse; Howard Hughes Medical Institute; Conseil Départemental des Alpes Maritimes; University of Cambridge; Doris Duke Charitable Foundation; Boehringer Ingelheim; Chan Zuckerberg Initiative; Stiftelsen för Strategisk Forskning; Richard and Susan Smith Family Foundation; Heart and Stroke Foundation of Canada; National Science Foundation","keywords":"TMPRSS2; Biology; Immunology; Cell type; Proteases; Coronavirus; Tropism; Viral entry; Tissue tropism; Transcriptome; Cell; Gene expression; Virology; Virus; Gene; Pathology; Medicine; Viral replication; Genetics; Disease; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001544214,0.0009341061,0.01082078,0.001627105,0.0001076686,0.00003948263,0.0005090977,0.001989331,0.00008052742],"category_scores_gemma":[0.001037081,0.0005740036,0.003271597,0.005455661,0.000770346,0.00006002225,0.0003071749,0.002703693,0.000007807839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001043886,"about_ca_system_score_gemma":0.0004330314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001049471,"about_ca_topic_score_gemma":0.0001487456,"domain_scores_codex":[0.9943235,0.0004311259,0.001465711,0.001220246,0.001845294,0.0007141451],"domain_scores_gemma":[0.9956682,0.001235658,0.0007135018,0.001448421,0.000817396,0.0001168133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008944998,0.0008481548,0.0008551004,0.05921626,0.3494633,0.001806784,0.0006309406,4.330418e-8,0.008231813,0.0001404315,0.005748042,0.5729697],"study_design_scores_gemma":[0.0005489193,0.0002280976,0.000005984258,0.00168305,0.3299693,0.0000969081,0.00008424479,0.000003678512,0.004034172,0.000005475803,0.6630731,0.0002671211],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001356027,0.9954686,0.00002696696,0.0004141338,0.0003106597,0.000902097,0.0001718048,0.00006115402,0.001288541],"genre_scores_gemma":[0.0003885502,0.9858084,0.000260399,0.01218263,0.0005820972,0.00007416024,0.0003317238,0.0001132898,0.0002586933],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.657325,"threshold_uncertainty_score":0.9996712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.180615728563271,"score_gpt":0.4653066151737575,"score_spread":0.2846908866104865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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