{"id":"W3134246207","doi":"10.1101/2021.03.05.434048","title":"A genetically encoded fluorescent biosensor for extracellular L-lactate","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre Hospitalier de l’Université de Montréal; University of Alberta; University of Calgary","funders":"","keywords":"Extracellular; Biosensor; Fluorescence; Green fluorescent protein; Cell; Biochemistry; Chemistry; Cell biology; Biology; Biophysics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958093,0.000337762,0.0001817963,0.0001900997,0.0001242801,0.0003776107,0.0004481496,0.000590218,0.0006529519],"category_scores_gemma":[0.0003305136,0.0001245229,0.0001289057,0.000144187,0.0003457777,0.0002392704,0.0002532486,0.0006293812,0.0003985702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006214995,"about_ca_system_score_gemma":0.0002365159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007836344,"about_ca_topic_score_gemma":0.0006822135,"domain_scores_codex":[0.999805,0.00002672295,0.000008292986,0.00005450171,0.00007522492,0.00003019248],"domain_scores_gemma":[0.999869,0.00003276766,0.00003393076,0.00001073017,0.00002790583,0.00002567146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001416737,0.000004981512,0.00004440605,0.00001266406,7.77573e-7,0.00001313894,0.000006270219,0.00005668429,0.999042,0.000142013,0.0000445185,0.0006183069],"study_design_scores_gemma":[0.000004127882,0.0000242303,0.0002976573,0.000002643112,0.000002505471,0.00006935145,0.000005919875,0.0009293805,0.9970386,0.00003937551,0.001582363,0.000003876906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.903098,0.002314839,0.08781603,0.001111406,0.0001721804,0.00006951538,0.0008603251,0.0005907736,0.003966995],"genre_scores_gemma":[0.9389889,0.0008335891,0.05264528,0.0002587663,0.00002637766,0.00005629332,0.0007959649,0.00007156118,0.006323267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007836344,"threshold_uncertainty_score":0.00450933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232054788300416,"score_gpt":0.2193454993660623,"score_spread":0.2070249514830582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}