{"id":"W3134327013","doi":"10.1038/s41571-021-00491-3","title":"The ten genes for breast (and ovarian) cancer susceptibility","year":2021,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"PALB2; CHEK2; Breast cancer; Ovarian cancer; Gene; Oncology; Biology; Medicine; Cancer; Genetics; Mutation; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009250292,0.001351345,0.001420161,0.001504889,0.0001871518,0.0009273351,0.001207198,0.00141711,0.00327443],"category_scores_gemma":[0.001108701,0.0002993397,0.0004001826,0.001689041,0.000756705,0.0008805844,0.0007994419,0.002448797,0.001680488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008261667,"about_ca_system_score_gemma":0.001302031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001563125,"about_ca_topic_score_gemma":0.002653897,"domain_scores_codex":[0.9997477,0.00004951838,0.00002963998,0.0000362935,0.0001023167,0.00003442931],"domain_scores_gemma":[0.9996189,0.0002108288,0.00003651044,0.00001095005,0.0000831893,0.00003967031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001168167,0.00003797033,0.0002835867,0.004775088,0.00007346967,0.000210017,0.00002798342,0.0004287458,0.001836935,0.005154725,0.07165037,0.9154043],"study_design_scores_gemma":[0.00005580222,0.00006105079,0.00105619,0.002794989,0.0001440212,0.0009752623,0.0000432718,0.0001000053,0.0004587439,0.004363901,0.9899275,0.00001925704],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000845117,0.9975223,0.0002151473,0.0007818604,0.0004085647,0.000004354036,0.0000403967,0.00001358321,0.0009293044],"genre_scores_gemma":[0.0005369685,0.9977343,0.0002290428,0.0004625419,0.0002664268,0.000006850819,0.00006176371,0.000001593585,0.0007005227],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00327443,"threshold_uncertainty_score":0.01095408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1026514513785231,"score_gpt":0.5104314512757606,"score_spread":0.4077799998972375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}