{"id":"W3134332329","doi":"10.1016/j.annonc.2021.01.053","title":"38MO IND.236: A Canadian Cancer Trial Group (CCTG) phase Ib trial of combined CFI-402257 and weekly paclitaxel (Px) in patients with HER2-negative (HER2-) advanced breast cancer (BC)","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University Health Network; Queen's University; Ottawa Hospital; Princess Margaret Cancer Centre","funders":"Ontario Institute for Cancer Research; Canadian Cancer Society; Stand Up To Cancer Canada; Government of Ontario","keywords":"Medicine; Taxane; Internal medicine; Neutropenia; Febrile neutropenia; Chemotherapy; Breast cancer; Nausea; Adverse effect; Gastroenterology; Cancer; Oncology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004223064,0.001299772,0.001339962,0.0004689421,0.0005615692,0.001021813,0.0008307053,0.001301286,0.02485039],"category_scores_gemma":[0.0004866846,0.0003573897,0.0009887943,0.0004311993,0.0005803967,0.0003971113,0.0003634137,0.002851557,0.003965007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001694361,"about_ca_system_score_gemma":0.003458976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01334716,"about_ca_topic_score_gemma":0.05927125,"domain_scores_codex":[0.9998112,0.00004475518,0.000004952159,0.00002630028,0.00002217278,0.00009054368],"domain_scores_gemma":[0.999742,0.00001794588,0.00002072087,0.00001071811,0.00001110603,0.0001974967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5994499,0.01940741,0.005469878,0.001461689,0.001251499,0.0005929751,0.000209286,0.003171334,0.02240188,0.002117047,0.08447785,0.2599893],"study_design_scores_gemma":[0.7854676,0.1437083,0.01906908,0.0001682275,0.0006816974,0.00067082,0.00009547052,0.002239065,0.003034021,0.001016375,0.04376822,0.00008105292],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9072313,0.007886668,0.0006297717,0.00595355,0.00121741,0.004919374,0.02014094,0.001059207,0.05096176],"genre_scores_gemma":[0.9023964,0.005419215,0.002165222,0.004695583,0.0004993746,0.003010939,0.01937417,0.0001422935,0.06229673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02485039,"threshold_uncertainty_score":0.08313286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04667935103306406,"score_gpt":0.4074620828819004,"score_spread":0.3607827318488364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}