{"id":"W3134372618","doi":"10.3390/microorganisms9030494","title":"SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Education, Science and Technology; National Research Foundation of Korea; National Research Foundation","keywords":"Inflammasome; AIM2; Caspase 1; Viral replication; Biology; Innate immune system; Cell biology; Secretion; Virology; Chemistry; Virus; Immune system; Immunology; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009326295,0.0001511277,0.0001352366,0.00001912134,0.0001776657,0.00008691412,0.00009643746,0.0001204661,0.00001372873],"category_scores_gemma":[0.00006961494,0.0001154223,0.00004234521,0.00006690368,0.0002415547,0.00001090721,0.0001912324,0.0001055889,0.000004592874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006255606,"about_ca_system_score_gemma":0.00005411225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000541735,"about_ca_topic_score_gemma":0.00008431897,"domain_scores_codex":[0.9992433,0.00007215945,0.0001510856,0.0002724918,0.00006830692,0.0001926229],"domain_scores_gemma":[0.9995713,0.00001231662,0.00005712135,0.0002612513,0.00007666922,0.00002140713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008143936,0.00001090473,0.0002652848,0.000016208,0.00004426019,0.000004731102,0.0003110664,6.13675e-7,0.9976178,0.0001654322,0.0003058774,0.001176367],"study_design_scores_gemma":[0.001989911,0.00004131488,0.002703904,0.000008885785,0.0000191764,0.0001297831,0.0003729064,0.000007793225,0.9861244,0.0002118012,0.008225524,0.0001646115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973044,0.000915288,0.0001521121,0.0009745146,0.00007264103,0.0002465794,0.0000100637,0.000009963193,0.0003143856],"genre_scores_gemma":[0.9983,0.0001694692,0.0003322718,0.0006558095,0.00008664945,0.00001884686,0.0001082777,0.00002149132,0.0003072161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01149343,"threshold_uncertainty_score":0.4706783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005048840603984346,"score_gpt":0.2088136372905035,"score_spread":0.2037647966865191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}