{"id":"W3134372618","doi":"10.3390/microorganisms9030494","title":"SARS-CoV-2 Nonstructural Proteins 1 and 13 Suppress Caspase-1 and the NLRP3 Inflammasome Activation","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Ministry of Education, Science and Technology; National Research Foundation of Korea; National Research Foundation","keywords":"Inflammasome; AIM2; Caspase 1; Viral replication; Biology; Innate immune system; Cell biology; Secretion; Virology; Chemistry; Virus; Immune system; Immunology; Biochemistry; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408278,0.0003513353,0.0002921032,0.0001926514,0.00008919747,0.0002124808,0.0001095582,0.000213711,0.001497743],"category_scores_gemma":[0.0001423755,0.00008904831,0.0003436155,0.000145672,0.0001748807,0.0001752351,0.0001502924,0.0004731233,0.0004575145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150768,"about_ca_system_score_gemma":0.0002470526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002209543,"about_ca_topic_score_gemma":0.0003813005,"domain_scores_codex":[0.9998639,0.00002682922,0.00001809869,0.0000206934,0.00003671816,0.00003372325],"domain_scores_gemma":[0.9999137,0.00001596266,0.00002584717,0.00001131801,0.00001280696,0.00002043296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001757899,0.00005642277,0.00007971644,0.00002929102,0.000003548409,0.00002234947,0.00000660888,0.00003245462,0.9983848,0.00004227773,0.0000244632,0.001142189],"study_design_scores_gemma":[0.00004270368,0.0006459409,0.004669817,0.000007785547,0.00001031581,0.0002338908,0.00002025431,0.000571437,0.9919241,0.00006601861,0.001804272,0.000003481593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920201,0.00273973,0.002609337,0.00009695435,0.00004136585,0.00005053442,0.0003851533,0.00006405963,0.00199272],"genre_scores_gemma":[0.9913138,0.001430496,0.002927436,0.00009405873,0.00001821571,0.00007479167,0.0009441394,0.00001851547,0.003178561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497743,"threshold_uncertainty_score":0.005010486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005048840603984346,"score_gpt":0.2088136372905035,"score_spread":0.2037647966865191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}