{"id":"W3134419041","doi":"10.1002/sctm.20-0520","title":"Persistence of CRISPR/Cas9 Gene Edited Hematopoietic Stem Cells Following Transplantation: A Systematic Review and Meta-Analysis of Preclinical Studies","year":2021,"lang":"en","type":"review","venue":"Stem Cells Translational Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Canadian Blood Services; Ottawa Hospital","funders":"","keywords":"CRISPR; Biology; Stem cell; Haematopoiesis; Genome editing; Transplantation; Genetic enhancement; Progenitor cell; Immunology; Gene; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001005968,0.0004908919,0.007118778,0.0002151169,0.00003918997,0.000005088745,0.0002320808,0.0002479137,0.00004167826],"category_scores_gemma":[0.00002627395,0.0003478198,0.002464398,0.0006551575,0.000145125,0.000004981772,0.00002877693,0.0001525209,6.3413e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009644151,"about_ca_system_score_gemma":0.0001140563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002173927,"about_ca_topic_score_gemma":0.000005379043,"domain_scores_codex":[0.9960636,0.0003856008,0.002197537,0.0006194281,0.0005426062,0.0001912368],"domain_scores_gemma":[0.9977978,0.0005856718,0.0006913352,0.0005353021,0.0002832644,0.0001065748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000004832975,0.00003784863,6.484133e-7,0.8660008,0.1321766,0.00001533184,0.000351292,0.0001488824,0.0008201554,0.000009677489,0.00005343909,0.0003804637],"study_design_scores_gemma":[0.0002849046,0.0001425556,4.044868e-7,0.04857501,0.9447917,0.0000454842,0.0002421705,0.00001929638,0.003445666,0.000001323495,0.002118311,0.0003331473],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002488713,0.9938762,0.004256254,0.00009391174,0.0001740712,0.001247635,0.0003037637,0.000006516684,0.00001682367],"genre_scores_gemma":[0.001538589,0.9972108,0.0004238005,0.00005415632,0.00006360448,0.0001381419,0.0003214477,0.00003493899,0.000214501],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8174258,"threshold_uncertainty_score":0.9998974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1196715673767616,"score_gpt":0.4064870121227692,"score_spread":0.2868154447460076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}