{"id":"W3134419041","doi":"10.1002/sctm.20-0520","title":"Persistence of CRISPR/Cas9 Gene Edited Hematopoietic Stem Cells Following Transplantation: A Systematic Review and Meta-Analysis of Preclinical Studies","year":2021,"lang":"en","type":"review","venue":"Stem Cells Translational Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Canadian Blood Services; Ottawa Hospital","funders":"","keywords":"CRISPR; Biology; Stem cell; Haematopoiesis; Genome editing; Transplantation; Genetic enhancement; Progenitor cell; Immunology; Gene; Genetics; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01575181,0.001701548,0.01358152,0.008918111,0.0005405005,0.003244327,0.002088869,0.001661516,0.003438008],"category_scores_gemma":[0.04200272,0.001109576,0.01928917,0.01063504,0.0007603612,0.00177966,0.001508744,0.001225118,0.0003373573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002780864,"about_ca_system_score_gemma":0.004598757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004827841,"about_ca_topic_score_gemma":0.01197337,"domain_scores_codex":[0.9854375,0.005158612,0.00588633,0.001526184,0.001589659,0.0004017148],"domain_scores_gemma":[0.9422637,0.04393353,0.008492843,0.001437631,0.003485737,0.0003866391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0009440195,0.0000137434,0.004425803,0.8182063,0.1583803,0.0001668217,0.0001349803,0.0002684492,0.0004673603,0.0001927191,0.001009874,0.01578973],"study_design_scores_gemma":[0.0004643745,0.0002833028,0.01032284,0.2101827,0.7680168,0.0003665348,0.0001884758,0.0001802057,0.0004288578,0.0004617359,0.009049525,0.00005462032],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003840568,0.9934624,0.0004167498,0.0002474486,0.0000986729,0.0001978153,0.001447439,0.00001602966,0.0002728487],"genre_scores_gemma":[0.1295142,0.8637174,0.001761396,0.001349944,0.0001794461,0.001030013,0.0021136,0.00004775662,0.0002861203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01575181,"threshold_uncertainty_score":0.08330452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1196715673767616,"score_gpt":0.4064870121227692,"score_spread":0.2868154447460076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}