{"id":"W3134446941","doi":"10.1021/acs.orglett.0c04212","title":"Using Catalysts To Make Catalysts: Titanium-Catalyzed Hydroamination To Access <i>P,N</i>-Ligands for Assembling Catalysts in One Pot","year":2021,"lang":"en","type":"article","venue":"Organic Letters","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Université de Bordeaux; Agence Nationale de la Recherche; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Hydroamination; Chemistry; Protonolysis; Catalysis; Steric effects; Combinatorial chemistry; Yield (engineering); Metathesis; Titanium; Transition metal; Salt metathesis reaction; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001614025,0.0005964564,0.0002103032,0.0002800935,0.0001798705,0.00042295,0.0006323773,0.0004093036,0.001929566],"category_scores_gemma":[0.0003227157,0.0002819276,0.0002352139,0.0001908403,0.0002509067,0.0004501104,0.0004263487,0.0007395233,0.001391775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003957179,"about_ca_system_score_gemma":0.0002830259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003491114,"about_ca_topic_score_gemma":0.0009180274,"domain_scores_codex":[0.9997694,0.00001413945,0.00002377901,0.0000750371,0.00007817319,0.00003940749],"domain_scores_gemma":[0.9999102,0.00001472158,0.00002946036,0.00001677332,0.00001322054,0.00001560462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002806166,0.00001148864,0.00006451803,0.00009116704,0.000006584498,0.00009932482,0.00002577569,0.00006370401,0.99555,0.0004760309,0.0001358284,0.003447598],"study_design_scores_gemma":[0.000005215553,0.00003539545,0.0001314633,0.000003259785,0.00000457274,0.0001339091,0.000007602399,0.0002498237,0.9962389,0.00005413879,0.003131836,0.000003732197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8561003,0.002302764,0.1080241,0.000415788,0.0002722437,0.0005463564,0.00149608,0.002025386,0.02881687],"genre_scores_gemma":[0.9353645,0.001573762,0.05188278,0.0001376042,0.00003264672,0.000246353,0.001000789,0.000327068,0.009434326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001929566,"threshold_uncertainty_score":0.006455064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04152542534353565,"score_gpt":0.3002760151908056,"score_spread":0.25875058984727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}