{"id":"W3134486170","doi":"10.1055/s-0041-1723030","title":"Assessing Toxicity in Drug Trials in Liver Disease","year":2021,"lang":"en","type":"article","venue":"Seminars in Liver Disease","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Drug; Clinical trial; Medicine; Intensive care medicine; Liver injury; Drug trial; Liver toxicity; Drug toxicity; Liver disease; Pharmacology; Hepatitis; Liver function; Toxicity; Disease; Drug development; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.367126,0.001937607,0.006251841,0.00724765,0.00110379,0.007664696,0.003489732,0.002935616,0.004680374],"category_scores_gemma":[0.3162169,0.00102191,0.004272634,0.009150489,0.005836662,0.004935776,0.005263662,0.003726871,0.001355251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004551259,"about_ca_system_score_gemma":0.00639176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009766797,"about_ca_topic_score_gemma":0.002197202,"domain_scores_codex":[0.4330635,0.4881285,0.03884604,0.004429126,0.03440604,0.001126758],"domain_scores_gemma":[0.5005255,0.3464722,0.08312106,0.01945636,0.04812348,0.002301372],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007215264,0.0006133904,0.1017037,0.06376579,0.0090021,0.000837531,0.004044776,0.00590469,0.007467584,0.04433242,0.01884796,0.7362648],"study_design_scores_gemma":[0.002251526,0.03841997,0.1946776,0.04702095,0.01360762,0.006116302,0.003144272,0.01906344,0.03046826,0.1336385,0.5106012,0.0009903926],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04168032,0.5821458,0.2926883,0.01793227,0.006673894,0.01434949,0.002807576,0.0009444629,0.04077797],"genre_scores_gemma":[0.3748257,0.2224163,0.358209,0.01342033,0.004039597,0.01509195,0.002653944,0.0004575798,0.008885699],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.367126,"threshold_uncertainty_score":0.7804464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1928630481267214,"score_gpt":0.4564016694823199,"score_spread":0.2635386213555986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}