{"id":"W3134486170","doi":"10.1055/s-0041-1723030","title":"Assessing Toxicity in Drug Trials in Liver Disease","year":2021,"lang":"en","type":"article","venue":"Seminars in Liver Disease","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Drug; Clinical trial; Medicine; Intensive care medicine; Liver injury; Drug trial; Liver toxicity; Drug toxicity; Liver disease; Pharmacology; Hepatitis; Liver function; Toxicity; Disease; Drug development; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004417795,0.0003618457,0.0006982769,0.0004577989,0.0001806237,0.00009642733,0.0002885766,0.0003368632,0.001417579],"category_scores_gemma":[0.002426661,0.0004084162,0.0002574305,0.0009287173,0.0001690492,0.0007431204,0.0002084774,0.001493597,0.0001214118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005208612,"about_ca_system_score_gemma":0.0006503903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003581431,"about_ca_topic_score_gemma":0.001323815,"domain_scores_codex":[0.9921185,0.005160537,0.0009512586,0.0007579275,0.0003011518,0.0007106013],"domain_scores_gemma":[0.9970929,0.001553236,0.0002378106,0.0003708515,0.00007625383,0.000668943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004058362,0.006603072,0.80473,0.001098799,0.0001092773,0.02218019,0.005283787,0.004777053,0.01444904,0.001309938,0.002557591,0.1328429],"study_design_scores_gemma":[0.007525408,0.00005245499,0.904565,0.001677959,0.0004127141,0.00002142785,0.001213924,0.02538087,0.03299056,0.006845683,0.01788015,0.001433883],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873592,0.007416078,0.00003766299,0.0008397195,0.001167848,0.000984917,0.0001395965,0.00006895074,0.001986051],"genre_scores_gemma":[0.9937107,0.003026189,0.0001582858,0.001745493,0.0002790952,0.0002436567,0.0000810821,0.00003428962,0.0007212158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.131409,"threshold_uncertainty_score":0.9998367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1928630481267214,"score_gpt":0.4564016694823199,"score_spread":0.2635386213555986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}