{"id":"W3134501171","doi":"10.1101/2021.03.05.433782","title":"Pharmacological targeting of a PWWP domain demonstrates cooperative control of NSD2 localization","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; National Institutes of Health; Ontario Genomics; Genome Canada; McGill University; Genentech; Bayer; Pfizer; National Science Foundation","keywords":"Chromatin; Nucleolus; Histone; Transcription (linguistics); Genetics; Biology; Cell biology; DNA; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077801,0.0002491294,0.0001561928,0.0001115541,0.0001593667,0.0002341166,0.0002410525,0.000208682,0.001180841],"category_scores_gemma":[0.00008071802,0.0001179606,0.0001708997,0.00009132341,0.0003172994,0.000103703,0.000203648,0.0004833678,0.0002389157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004118147,"about_ca_system_score_gemma":0.0001398598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005560316,"about_ca_topic_score_gemma":0.001226595,"domain_scores_codex":[0.9998846,0.00001507502,0.00001012255,0.00002456616,0.00003846697,0.00002713587],"domain_scores_gemma":[0.9999254,0.00001895134,0.00001938665,0.00000940355,0.000006284442,0.0000205364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004957855,0.00001681825,0.00002919402,0.00001306734,0.000002145002,0.00001167632,0.000003206806,0.00003422071,0.9994803,0.00005509078,0.00001404857,0.0002906461],"study_design_scores_gemma":[0.00001567938,0.0001232794,0.000747564,0.000001533637,0.000004414086,0.00006350198,0.000006883382,0.0005518406,0.9976908,0.00001554195,0.0007769926,0.000001982811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954269,0.0004622064,0.002442539,0.00007096105,0.00001843482,0.00003187108,0.0002057729,0.00007174194,0.001269615],"genre_scores_gemma":[0.9969477,0.0002667044,0.001570668,0.00003109655,0.000004623227,0.00002661706,0.0001597207,0.00001210833,0.0009806973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180841,"threshold_uncertainty_score":0.003950238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009488283483469745,"score_gpt":0.2379193282900963,"score_spread":0.2284310448066265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}