{"id":"W3134513457","doi":"10.1007/s12035-021-02351-8","title":"Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Munster Technological University; Science Foundation Ireland","keywords":"Dopaminergic; Neurodegeneration; Substantia nigra; Neurotrophic factors; Neuroprotection; Neuroscience; Neurite; Neurotrophin; Niclosamide; Neurotoxin; SMAD; Pharmacology; Biology; Dopamine; Cell biology; Medicine; Signal transduction; Internal medicine; Endocrinology; Biochemistry; In vitro; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001442269,0.0003817551,0.0004791694,0.00009405897,0.0001586717,0.00006140518,0.0000932437,0.0001508995,0.000005016329],"category_scores_gemma":[0.0003312121,0.0002964762,0.00007798927,0.0002886625,0.000172507,0.00008447285,0.0002750267,0.0004773163,0.000002195817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002343542,"about_ca_system_score_gemma":0.0001368477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000997833,"about_ca_topic_score_gemma":0.000156275,"domain_scores_codex":[0.9972274,0.0007843105,0.0003683565,0.001012164,0.0001416574,0.0004660863],"domain_scores_gemma":[0.9991032,0.0001012409,0.00009980783,0.0004363415,0.00006709721,0.0001922389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001673898,0.0002684118,0.003531585,0.00008509618,0.00004459858,0.005947283,0.0001015227,0.00001151699,0.9864438,0.001005849,0.00001756986,0.002375383],"study_design_scores_gemma":[0.01071514,0.00450199,0.1795066,0.000154572,0.0003578284,0.006099424,0.00006072045,0.004066996,0.7865619,0.001340668,0.005741641,0.0008925578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911856,0.0007561701,0.00007685016,0.006322625,0.0001504258,0.001291856,0.00002870504,0.0000552586,0.0001324831],"genre_scores_gemma":[0.9940115,0.0003911694,0.0002777526,0.004921889,0.00004627812,0.000163562,0.00006365087,0.00006149666,0.0000627569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1998819,"threshold_uncertainty_score":0.9999487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397192699495619,"score_gpt":0.2421904885260001,"score_spread":0.2282185615310439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}