{"id":"W3134513457","doi":"10.1007/s12035-021-02351-8","title":"Quinacrine and Niclosamide Promote Neurite Growth in Midbrain Dopaminergic Neurons Through the Canonical BMP-Smad Pathway and Protect Against Neurotoxin and α-Synuclein-Induced Neurodegeneration","year":2021,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Munster Technological University; Science Foundation Ireland","keywords":"Dopaminergic; Neurodegeneration; Substantia nigra; Neurotrophic factors; Neuroprotection; Neuroscience; Neurite; Neurotrophin; Niclosamide; Neurotoxin; SMAD; Pharmacology; Biology; Dopamine; Cell biology; Medicine; Signal transduction; Internal medicine; Endocrinology; Biochemistry; In vitro; Disease; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017441,0.0002348934,0.0002197681,0.0002613472,0.0001908678,0.0002044305,0.0002081493,0.0002272391,0.001766232],"category_scores_gemma":[0.00008021282,0.0001058438,0.0002275153,0.00008039714,0.0001735686,0.0002383578,0.0001451598,0.0004329389,0.0002549371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259199,"about_ca_system_score_gemma":0.0003117295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001654335,"about_ca_topic_score_gemma":0.005716565,"domain_scores_codex":[0.9999329,0.00001126599,0.000006578166,0.000009080354,0.00001829183,0.00002195633],"domain_scores_gemma":[0.9999477,0.000005450271,0.0000128772,0.000004495871,0.0000128674,0.00001665273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006891629,0.00007663381,0.0003488744,0.00009651743,0.00001430198,0.0001289697,0.00002836446,0.00006584541,0.9959644,0.0001999857,0.0001253078,0.002261585],"study_design_scores_gemma":[0.00006940609,0.0008069351,0.009960507,0.00001729632,0.00003832658,0.0003304044,0.0002206661,0.0007702006,0.9844766,0.0001274101,0.003175178,0.000007049877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937003,0.001989503,0.0009371909,0.0002237643,0.00004475302,0.00002366212,0.0003543381,0.00004897681,0.002677492],"genre_scores_gemma":[0.9932612,0.001649203,0.0009020379,0.00005709543,0.000009702062,0.00003017678,0.0003319891,0.00001013105,0.003748497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001766232,"threshold_uncertainty_score":0.005908668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397192699495619,"score_gpt":0.2421904885260001,"score_spread":0.2282185615310439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}