{"id":"W3134530079","doi":"10.1161/circheartfailure.120.007351","title":"In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure","year":2021,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Bristol-Myers Squibb","keywords":"Apelin; Agonist; Heart failure; Medicine; Internal medicine; Pharmacology; Endocrinology; Receptor; Cardiac function curve; Contractility","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001070621,0.0002164445,0.0005168497,0.0003662254,0.00007098563,0.00003217049,0.00005231281,0.0003903165,0.0008543095],"category_scores_gemma":[0.001076236,0.0002098683,0.000167176,0.0007252257,0.0001122764,0.0001079114,0.00004272965,0.0002891574,0.0000371957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005018869,"about_ca_system_score_gemma":0.001156161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002474097,"about_ca_topic_score_gemma":0.0002708805,"domain_scores_codex":[0.9971749,0.000343019,0.0006229887,0.0005733308,0.0008798431,0.0004058718],"domain_scores_gemma":[0.998508,0.0001942813,0.00009140817,0.0003359244,0.0006331452,0.000237235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006126027,0.0004679971,0.003893548,0.0001600694,0.00006587681,0.00002527043,0.0003340843,0.00025261,0.9892517,0.00002958461,0.002276399,0.002630273],"study_design_scores_gemma":[0.03792715,0.001403233,0.0706765,0.001110451,0.0006567977,0.0004781059,0.002394518,0.1329292,0.6708291,0.001273733,0.0794585,0.000862751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662518,0.0007344628,0.0003729484,0.03048005,0.00009382452,0.001940968,0.0000323674,0.00002495024,0.00006866049],"genre_scores_gemma":[0.9927437,0.00002753922,0.005854662,0.0003605988,0.0001569316,0.0002231013,0.0003329119,0.00003589049,0.0002646146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3184226,"threshold_uncertainty_score":0.935409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03600778754905022,"score_gpt":0.342819503362335,"score_spread":0.3068117158132848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}