{"id":"W3134530079","doi":"10.1161/circheartfailure.120.007351","title":"In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure","year":2021,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Bristol-Myers Squibb","keywords":"Apelin; Agonist; Heart failure; Medicine; Internal medicine; Pharmacology; Endocrinology; Receptor; Cardiac function curve; Contractility","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004008608,0.0005046357,0.0004368344,0.0002819604,0.0001730623,0.0002914309,0.0002177791,0.0003941871,0.002162809],"category_scores_gemma":[0.0001727785,0.0002036257,0.0003400448,0.0001660553,0.0002011773,0.000247063,0.00008660512,0.0008117286,0.0005560703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001639045,"about_ca_system_score_gemma":0.0002433078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003364886,"about_ca_topic_score_gemma":0.0006138798,"domain_scores_codex":[0.9998438,0.00003753603,0.00001413481,0.000025537,0.00004408789,0.00003480091],"domain_scores_gemma":[0.9998791,0.00002863887,0.00002858801,0.00001036851,0.00001830035,0.0000348727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001678239,0.001150122,0.0001483968,0.0001012865,0.00001465892,0.00005505509,0.00002076857,0.0002353406,0.9921787,0.00003471102,0.0001147925,0.004267872],"study_design_scores_gemma":[0.001161815,0.06129223,0.008499322,0.00002068562,0.0002074584,0.0004893219,0.00008544842,0.002774112,0.9215806,0.00005796934,0.00381271,0.00001847358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930382,0.002608584,0.001870062,0.0001336863,0.00007074994,0.0001430703,0.0004051999,0.00005591856,0.001674447],"genre_scores_gemma":[0.9884211,0.002950944,0.004336478,0.0001097195,0.00009127033,0.0003133428,0.0009446035,0.00001794433,0.002814525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002162809,"threshold_uncertainty_score":0.007235348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03600778754905022,"score_gpt":0.342819503362335,"score_spread":0.3068117158132848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}