{"id":"W3134537818","doi":"10.7554/elife.58430","title":"DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia","year":2021,"lang":"en","type":"review","venue":"eLife","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Mental Health; Medical Research Council; Seventh Framework Programme; Karolinska Institutet; National Institutes of Health; Vetenskapsrådet; Science Foundation Ireland; Academy of Finland; National Institute for Health and Care Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Psychosis; Schizophrenia (object-oriented programming); DNA methylation; Clozapine; Methylation; Biology; Medicine; Bioinformatics; Genetics; Psychiatry; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004909944,0.0003323651,0.00188087,0.0003185546,0.00004736,0.00003545583,0.0001047173,0.0003134775,0.00006668612],"category_scores_gemma":[0.00009395531,0.0002708763,0.001398056,0.0005774842,0.00003704581,0.000003595516,0.00004839808,0.00007845474,0.000001618896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003905718,"about_ca_system_score_gemma":0.000132147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008218836,"about_ca_topic_score_gemma":0.000261734,"domain_scores_codex":[0.9977324,0.0005449135,0.0008247709,0.000571055,0.0001670292,0.0001598207],"domain_scores_gemma":[0.9987097,0.00007486106,0.0004500268,0.0005780252,0.0001116011,0.00007574237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002228789,0.0006807133,0.0003030017,0.00475189,0.3678047,0.00002056691,0.0001853551,0.0005432544,0.09647859,0.0004537423,0.0004470501,0.5281082],"study_design_scores_gemma":[0.0005233131,0.0004285599,0.0001051907,0.0002435765,0.2352562,9.36289e-7,0.00002079976,0.00003458924,0.0188844,0.00004336533,0.743802,0.0006570739],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003771122,0.9947554,0.0006458995,0.00001690236,0.00004278536,0.0004045606,0.0002140319,0.000003330098,0.0001459434],"genre_scores_gemma":[0.004755656,0.9906849,0.001986559,0.00001006034,0.0000687333,0.0001364008,0.001873571,0.00003065779,0.0004534343],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7433549,"threshold_uncertainty_score":0.9999744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0680903269807697,"score_gpt":0.3497032822512988,"score_spread":0.2816129552705291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}