{"id":"W3134565753","doi":"10.1038/s41467-021-21681-8","title":"Lipid regulation of hERG1 channel function","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; National Heart, Lung, and Blood Institute; Alberta Innovates; Killam Trusts; Canada Research Chairs; University of Alberta; Compute Canada","keywords":"Allosteric regulation; Ceramide; Gating; Sphingolipid; Biophysics; Ion channel; Molecular dynamics; Mutagenesis; Function (biology); Chemistry; Cell biology; Biochemistry; Biology; Mutation; Receptor; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290293,0.0001885695,0.0001602564,0.00007005544,0.0001470136,0.0002305316,0.0001933685,0.0001570819,0.0009710445],"category_scores_gemma":[0.0002172136,0.00006837538,0.0001372427,0.00005358062,0.0002469066,0.0002493452,0.0002057432,0.0002923116,0.0001805707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003500296,"about_ca_system_score_gemma":0.0001984098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007049022,"about_ca_topic_score_gemma":0.0004959903,"domain_scores_codex":[0.9999433,0.00001072317,0.00000262984,0.00001102825,0.00001764122,0.00001476304],"domain_scores_gemma":[0.9999455,0.00001628044,0.00001365658,0.000004502241,0.000009427068,0.00001057924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001060879,0.00001448756,0.0005426301,0.00002599983,0.000007311516,0.0000701489,0.00002167649,0.004417317,0.9930524,0.0005622869,0.00003512143,0.001144592],"study_design_scores_gemma":[0.00004371804,0.0001434018,0.004049623,0.000007674828,0.00001070576,0.0001615436,0.00006616548,0.05405056,0.9399099,0.0006263815,0.0009123959,0.00001789991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971316,0.0001660757,0.002000133,0.00005734323,0.000007464861,0.000006515583,0.00005293028,0.0000323656,0.00054549],"genre_scores_gemma":[0.9994542,0.00005874652,0.0003558423,0.00001142052,7.878009e-7,0.000002751311,0.0000202391,0.00000486301,0.00009101017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009710445,"threshold_uncertainty_score":0.003248453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01378516844498857,"score_gpt":0.2765578048521419,"score_spread":0.2627726364071534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}