{"id":"W3134582569","doi":"10.1016/j.stemcr.2021.02.002","title":"Opportunities and challenges with stem cell-based embryo models","year":2021,"lang":"en","type":"review","venue":"Stem Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Gairdner Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Organogenesis; Embryo; Morphogenesis; Computational biology; Stem cell; Embryogenesis; Bioinformatics; Model organism; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006455993,0.0007754159,0.001585131,0.0001803735,0.0001364138,0.0001151984,0.0002879601,0.0006860698,0.00001921734],"category_scores_gemma":[0.000003154633,0.0006232141,0.0004005305,0.0001256876,0.0001623054,0.000009414231,0.0003910195,0.0003651185,0.000005253115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005642379,"about_ca_system_score_gemma":0.001728769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009926161,"about_ca_topic_score_gemma":0.00001255746,"domain_scores_codex":[0.995904,0.0004133755,0.0008853397,0.001499985,0.0006427959,0.0006545362],"domain_scores_gemma":[0.9969862,0.00006092782,0.0007619187,0.001559227,0.000256193,0.0003755247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003644181,0.0003180392,0.000004096531,0.09610073,0.0005065215,0.0122714,0.00008568863,0.0001750325,0.00045022,0.00003716715,0.001933911,0.8880808],"study_design_scores_gemma":[0.0002022319,0.0002778405,2.340842e-7,0.003669272,0.0003537801,0.001099572,0.0003394302,0.00002146078,0.002544121,0.000003151378,0.9907388,0.0007500894],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002093693,0.9757705,0.0001332979,0.00004036445,0.0001722227,0.0009491606,0.00004640462,0.00003358546,0.02264509],"genre_scores_gemma":[0.001122525,0.9733247,0.0001066686,0.00002478137,0.0001412918,0.0002291436,0.0005911753,0.0001779668,0.02428178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9888049,"threshold_uncertainty_score":0.9996219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1076698582370745,"score_gpt":0.2916882705739289,"score_spread":0.1840184123368544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}