{"id":"W3134584173","doi":"10.1021/acs.biochem.0c00981","title":"Protein Substrates Engage the Lumen of O-GlcNAc Transferase’s Tetratricopeptide Repeat Domain in Different Ways","year":2021,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Tetratricopeptide; Glycosylation; Transferase; Cytoplasm; Biochemistry; Immunoprecipitation; Chemistry; Cell biology; Enzyme; Cytosol; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808294,0.0004953045,0.0002449366,0.0001333267,0.0001787557,0.0006790293,0.0001918783,0.0004322219,0.0006540125],"category_scores_gemma":[0.0002142678,0.0001961168,0.0003453897,0.0002027908,0.0002691384,0.0005632094,0.0003169593,0.0005171744,0.0004704148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336354,"about_ca_system_score_gemma":0.0001195487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002589053,"about_ca_topic_score_gemma":0.000369348,"domain_scores_codex":[0.9997825,0.00004753109,0.00001536117,0.00005133057,0.00005608211,0.00004711018],"domain_scores_gemma":[0.9998423,0.00002913246,0.00005037096,0.00002613363,0.00001839557,0.0000336729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006865231,0.00001225318,0.0006769681,0.00001510015,0.000006497536,0.00008153977,0.00001839135,0.00002695955,0.9983653,0.00009690052,0.00001549001,0.0006158374],"study_design_scores_gemma":[0.00000447837,0.0001119344,0.008790204,0.000006228413,0.0000113202,0.000551274,0.00006365899,0.0005009228,0.9884084,0.00009516403,0.001448088,0.000008301284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935896,0.00093181,0.003863251,0.000076471,0.00001856743,0.0000116568,0.0001028919,0.00003890217,0.001366855],"genre_scores_gemma":[0.9931315,0.0007070103,0.004052178,0.00009424953,0.000005896306,0.00001168063,0.0003841603,0.00002834146,0.001584958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006790293,"threshold_uncertainty_score":0.002187908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01390266698877764,"score_gpt":0.2457245888226889,"score_spread":0.2318219218339112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}