{"id":"W3134624884","doi":"10.15252/emmm.202013349","title":"WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer","year":2021,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; University of Toronto; Duke-NUS Medical School; Medical Research Council; National Medical Research Council; National Research Foundation Singapore; National Research Foundation","keywords":"Wnt signaling pathway; Cancer; Biology; Cancer research; Cell biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001202622,0.0001773067,0.0001799956,0.0003116032,0.0001308949,0.0003814423,0.0001088897,0.0002018146,0.002414869],"category_scores_gemma":[0.000115001,0.0001161247,0.0001990738,0.0002099399,0.0001720486,0.0001257135,0.0001785573,0.0003925975,0.0003610412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003994849,"about_ca_system_score_gemma":0.0001642528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005895518,"about_ca_topic_score_gemma":0.001100946,"domain_scores_codex":[0.9998994,0.00001667639,0.00001042848,0.00001894731,0.00003450429,0.00002017841],"domain_scores_gemma":[0.9999286,0.00001086719,0.00002418807,0.000009361508,0.000006680907,0.00002029187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001788163,0.00003712599,0.00138874,0.00005675758,0.00001755483,0.0002079814,0.00001027569,0.0001688836,0.9937299,0.0003108121,0.0001746394,0.003718512],"study_design_scores_gemma":[0.00003472083,0.0003797621,0.01142022,0.00001195064,0.0000330575,0.001626123,0.00003588358,0.001228714,0.9756831,0.0001492761,0.009391467,0.000005669328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897894,0.003253167,0.002042812,0.0002717292,0.00003887777,0.00003723551,0.0007663014,0.0001554476,0.00364502],"genre_scores_gemma":[0.9944561,0.001224039,0.0009942919,0.00008417596,0.00000388184,0.00002057204,0.0004550739,0.00001660081,0.00274524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002414869,"threshold_uncertainty_score":0.008078575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007005389592809282,"score_gpt":0.2560074800212407,"score_spread":0.2490020904284314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}