{"id":"W3134637465","doi":"10.1371/journal.pcbi.1008810","title":"A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19","year":2021,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Montreal Heart Institute; Memorial University of Newfoundland; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Université de Montréal; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Hemophagocytic lymphohistiocytosis; Neutrophil extracellular traps; Immunology; Thrombosis; Medicine; Coagulation; Coagulopathy; Platelet; Venous thrombosis; Disseminated intravascular coagulation; Platelet activation; Inflammation; Pathology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007357845,0.0006245723,0.0005402361,0.0007979011,0.000465613,0.0007979426,0.000585931,0.0007645055,0.003064158],"category_scores_gemma":[0.002699972,0.0002475893,0.001274583,0.0004693005,0.0003045326,0.0004966335,0.0005177981,0.0006952364,0.0002045405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006410604,"about_ca_system_score_gemma":0.001017582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01703002,"about_ca_topic_score_gemma":0.01598331,"domain_scores_codex":[0.9997895,0.00009650477,0.000007818165,0.00005724904,0.00001740368,0.00003140165],"domain_scores_gemma":[0.9986696,0.001064431,0.00007986558,0.0000412788,0.00007979525,0.00006501503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002878464,0.00009743593,0.02133402,0.0001158046,0.0003338354,0.0002716178,0.00006019811,0.9596972,0.001050962,0.005865406,0.001890717,0.008994926],"study_design_scores_gemma":[0.00001847868,0.00002720247,0.002854242,0.000007690537,0.00005103884,0.00002907296,0.00003071346,0.9923793,0.00009479278,0.004025649,0.0004759088,0.000005865423],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9079804,0.001237787,0.07675517,0.002923014,0.0001854853,0.00006071355,0.005495783,0.0005409893,0.004820516],"genre_scores_gemma":[0.9768139,0.0003458801,0.01678008,0.0002401778,0.00004280973,0.00007351863,0.003981399,0.0000393694,0.001682824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01703002,"threshold_uncertainty_score":0.03386176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06282025931985435,"score_gpt":0.3733068065443984,"score_spread":0.310486547224544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}