{"id":"W3134637465","doi":"10.1371/journal.pcbi.1008810","title":"A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19","year":2021,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; Montreal Heart Institute; Memorial University of Newfoundland; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Université de Montréal; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Hemophagocytic lymphohistiocytosis; Neutrophil extracellular traps; Immunology; Thrombosis; Medicine; Coagulation; Coagulopathy; Platelet; Venous thrombosis; Disseminated intravascular coagulation; Platelet activation; Inflammation; Pathology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001949349,0.0001384522,0.000734904,0.0007112597,0.00005593443,0.000007294364,0.00009111385,0.000103205,0.0001951719],"category_scores_gemma":[0.000628973,0.0001359826,0.0001485768,0.001493045,0.0001875116,0.00006712794,0.00008883499,0.0001216318,0.00001116218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854172,"about_ca_system_score_gemma":0.00111804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001752925,"about_ca_topic_score_gemma":0.0001393314,"domain_scores_codex":[0.9983966,0.0001575087,0.0007001599,0.0002927439,0.0002203493,0.0002325746],"domain_scores_gemma":[0.9985327,0.0007043056,0.0001784485,0.0001840625,0.0002820407,0.0001184695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001406704,0.00154758,0.4194483,0.0008282384,0.006519565,0.0001443978,0.003985783,0.05709198,0.4947101,0.00723601,0.0006712124,0.006410071],"study_design_scores_gemma":[0.01368275,0.001922216,0.6615931,0.0004856793,0.003695407,0.0001987429,0.002895972,0.2106235,0.08873783,0.009871663,0.005273532,0.001019567],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942504,0.001492567,0.001777157,0.002003818,0.00004470196,0.0002503179,0.00003934763,0.00001499244,0.0001267531],"genre_scores_gemma":[0.9960945,0.0002553218,0.001937319,0.001229879,0.00002191226,0.00003374237,0.000400501,0.0000109764,0.0000158035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4059723,"threshold_uncertainty_score":0.5545209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06282025931985435,"score_gpt":0.3733068065443984,"score_spread":0.310486547224544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}