{"id":"W3134652300","doi":"10.1371/journal.pgen.1009383","title":"TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infection","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Yunnan Provincial Science and Technology Department; Yunnan University; National Natural Science Foundation of China; McMaster University","keywords":"Autophagy; Biology; Innate immune system; Caenorhabditis elegans; Salmonella enterica; Ferritin; Host (biology); Salmonella; Pathogen; Microbiology; Immunity; Downregulation and upregulation; Regulator; Cell biology; Bacteria; Gene; Genetics; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310437,0.0004927482,0.0002693115,0.0004163683,0.0004370529,0.0005354729,0.0003156953,0.0004255956,0.001017647],"category_scores_gemma":[0.00008770944,0.0001624073,0.0002728603,0.0001243421,0.0003924579,0.0002589231,0.0004984019,0.0004043732,0.0003995933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005394614,"about_ca_system_score_gemma":0.0003604448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000771659,"about_ca_topic_score_gemma":0.0009492523,"domain_scores_codex":[0.9999034,0.00001269166,0.000006285311,0.00002799775,0.0000179121,0.00003161446],"domain_scores_gemma":[0.9999411,0.000005878447,0.00001686733,0.000004013511,0.000008195952,0.00002386388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003747277,0.00002398251,0.0009797092,0.0001900192,0.00001574647,0.0004840149,0.00004112976,0.0003749266,0.9879011,0.001972952,0.000664118,0.00697747],"study_design_scores_gemma":[0.00008090905,0.0006085878,0.03945741,0.0001110366,0.00006277781,0.001885338,0.0002811695,0.006946719,0.9168163,0.002514228,0.03116977,0.0000658151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539756,0.01249341,0.01705272,0.0009325123,0.0005186534,0.0001035695,0.001376194,0.001063986,0.01248338],"genre_scores_gemma":[0.9874127,0.002992379,0.005487425,0.0001157367,0.00003629907,0.0000414851,0.0004020466,0.00002850101,0.003483474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001017647,"threshold_uncertainty_score":0.003914118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326388955519081,"score_gpt":0.2432315990750589,"score_spread":0.2299677095198681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}