{"id":"W3134652300","doi":"10.1371/journal.pgen.1009383","title":"TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infection","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Yunnan Provincial Science and Technology Department; Yunnan University; National Natural Science Foundation of China; McMaster University","keywords":"Autophagy; Biology; Innate immune system; Caenorhabditis elegans; Salmonella enterica; Ferritin; Host (biology); Salmonella; Pathogen; Microbiology; Immunity; Downregulation and upregulation; Regulator; Cell biology; Bacteria; Gene; Genetics; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006105981,0.0001702405,0.0002144877,0.0000754736,0.0001312377,0.00005196841,0.00003599831,0.0001085421,0.0002043485],"category_scores_gemma":[0.0001536644,0.000159496,0.00005331314,0.0002467083,0.00003527283,0.00006214395,0.00003652953,0.0001700496,0.0000648442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003050426,"about_ca_system_score_gemma":0.0002036599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003292304,"about_ca_topic_score_gemma":0.0001545528,"domain_scores_codex":[0.9989412,0.00007431478,0.0001890788,0.0003129418,0.0002337521,0.0002486482],"domain_scores_gemma":[0.999159,0.00001878855,0.00006591384,0.000354565,0.0002286097,0.000173139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003009824,0.0005759746,0.0121812,0.0001439077,0.00006922318,0.0001654308,0.0007115799,0.0003945137,0.9820454,0.000134317,0.00006440298,0.003213138],"study_design_scores_gemma":[0.008571312,0.002007144,0.02363066,0.0001952746,0.001572027,0.0003684074,0.002520053,0.001754008,0.934474,0.00008781665,0.02391941,0.0008998777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946938,0.0004850882,0.0006451409,0.0001890127,0.0003526272,0.000254779,0.00001229953,0.0000918169,0.003275455],"genre_scores_gemma":[0.9970334,0.0001745746,0.001280359,0.0007393011,0.000324176,0.00001813969,0.0002087773,0.00005312042,0.000168189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04757133,"threshold_uncertainty_score":0.6504058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326388955519081,"score_gpt":0.2432315990750589,"score_spread":0.2299677095198681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}