{"id":"W3134659811","doi":"10.1038/s41573-021-00155-y","title":"Beyond immune checkpoint blockade: emerging immunological strategies","year":2021,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":477,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Immunotherapy; Tumor microenvironment; Immune checkpoint; Blockade; Cancer immunotherapy; Medicine; T cell; Immune system; Immunology; Cancer research; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.002458652,0.001514274,0.0090652,0.0005135267,0.0002032805,0.0005324635,0.001008993,0.002024451,0.004920062],"category_scores_gemma":[0.0008716736,0.0009872231,0.005556257,0.001847425,0.0003115439,0.0004868993,0.000764458,0.009165711,0.0004197811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000752004,"about_ca_system_score_gemma":0.002211315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002204167,"about_ca_topic_score_gemma":0.000008399574,"domain_scores_codex":[0.9918909,0.001409059,0.002675713,0.001624649,0.001229408,0.001170255],"domain_scores_gemma":[0.9954157,0.0004925079,0.001021887,0.002537886,0.0002487928,0.0002831525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003525584,0.0002786053,0.000001078633,0.04428711,0.0009448514,0.0005236643,0.00006710513,1.679479e-7,0.0003662962,0.0007170062,0.002445896,0.9503329],"study_design_scores_gemma":[0.0004916368,0.00008393684,0.000004022353,0.06320865,0.002039768,0.0008291233,0.0001541133,6.410844e-7,0.00009020486,0.00008083908,0.9322003,0.0008168195],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000196094,0.9801202,0.00001059164,0.0004236287,0.001175761,0.004026526,0.00007289935,0.0001274809,0.01402325],"genre_scores_gemma":[0.000006036737,0.9598526,0.0002862167,0.0001683445,0.001547881,0.0005687121,0.001442724,0.0002277158,0.03589981],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9495161,"threshold_uncertainty_score":0.9997606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04113483083086296,"score_gpt":0.3922663755111197,"score_spread":0.3511315446802568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}