{"id":"W3134682517","doi":"10.1128/aac.02406-20","title":"Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes","year":2021,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Elvitegravir; Dolutegravir; Integrase; Raltegravir; Mutant; Chemistry; Virology; Integrase inhibitor; DNA; Stereochemistry; Pharmacology; Biology; Human immunodeficiency virus (HIV); Viral load; Biochemistry; Antiretroviral therapy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031982,0.0001936141,0.0003299888,0.0001593694,0.0002056504,0.000334103,0.0002516506,0.0001810127,0.002947349],"category_scores_gemma":[0.0002816227,0.0001691146,0.0001373264,0.0001556859,0.000166789,0.0001849085,0.0001765395,0.0004761202,0.0005829736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000325731,"about_ca_system_score_gemma":0.0002315742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001674365,"about_ca_topic_score_gemma":0.002688124,"domain_scores_codex":[0.999864,0.00002111438,0.00001021246,0.00003386671,0.00003659022,0.00003422793],"domain_scores_gemma":[0.9998926,0.00001503956,0.00001788197,0.00002214725,0.00002303635,0.00002938218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005134574,0.00005023955,0.001240916,0.00007449393,0.00002977171,0.00007142801,0.00009420463,0.0001817652,0.9883462,0.0001765648,0.0002076557,0.009013336],"study_design_scores_gemma":[0.00003734749,0.00085879,0.01439227,0.00001324594,0.00003368531,0.0005779403,0.000101947,0.001658018,0.9742793,0.0001025127,0.007924876,0.00001999307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995559,0.00167481,0.0008512117,0.0000649326,0.00002093828,0.00001397963,0.0002928801,0.00005100737,0.001471239],"genre_scores_gemma":[0.9952689,0.0001891359,0.0005774928,0.00006180506,0.000002576181,0.00001287094,0.0005995028,0.000025425,0.003262295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002947349,"threshold_uncertainty_score":0.00985992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232588432934459,"score_gpt":0.2560057135053753,"score_spread":0.2436798291760307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}