{"id":"W3134813321","doi":"10.1186/s12885-021-08003-3","title":"Pre-clinical study of IRDye800CW-nimotuzumab formulation, stability, pharmacokinetics, and safety","year":2021,"lang":"en","type":"review","venue":"BMC Cancer","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital; University of Saskatchewan","funders":"Western Economic Diversification Canada","keywords":"Nimotuzumab; Medicine; Pharmacokinetics; Monoclonal antibody; Toxicity; Pharmacology; Epidermal growth factor receptor; Antibody; Oncology; Internal medicine; Cancer; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001186109,0.000492233,0.0006513288,0.0002075892,0.0001951306,0.000566191,0.0003812296,0.0004682562,0.002601137],"category_scores_gemma":[0.001626579,0.0001827144,0.0003998478,0.000215483,0.000373873,0.000348966,0.0001871275,0.0008848609,0.0008285527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004311391,"about_ca_system_score_gemma":0.0005585899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003486727,"about_ca_topic_score_gemma":0.0004038305,"domain_scores_codex":[0.9995589,0.0001343242,0.00002477219,0.00006806141,0.0001610635,0.00005288318],"domain_scores_gemma":[0.9994777,0.0001144597,0.0001301795,0.00003920234,0.0001447715,0.00009364487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03128449,0.01340201,0.005769679,0.001079316,0.0002747138,0.0008579293,0.0004410976,0.004125399,0.7867823,0.0005683278,0.003612172,0.1518025],"study_design_scores_gemma":[0.002808714,0.3360949,0.03306955,0.000114752,0.0006547665,0.002066039,0.0001913204,0.00737435,0.5746137,0.0004098583,0.04253022,0.00007174263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9821833,0.005993148,0.006192644,0.0002146407,0.0001223884,0.001506576,0.0004420927,0.0001505666,0.003194601],"genre_scores_gemma":[0.9882517,0.001935087,0.004114172,0.0002759495,0.00008374266,0.000732048,0.0007920181,0.00005488632,0.003760321],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002601137,"threshold_uncertainty_score":0.008701682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3541460664967972,"score_gpt":0.5736643055672753,"score_spread":0.2195182390704781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}