{"id":"W3134851073","doi":"10.1016/s2213-8587(21)00019-x","title":"Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Novo Nordisk Fonden; Novo Nordisk","keywords":"Medicine; Liraglutide; Placebo; Type 2 diabetes; Diabetes mellitus; Internal medicine; Antibody; Endocrinology; Immunology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005577567,0.0002251224,0.0006498594,0.00005238214,0.0001058492,0.00003978897,0.0002558129,0.000125426,0.00001909361],"category_scores_gemma":[0.0003782433,0.0001404176,0.0001177253,0.0002108282,0.0001651587,0.00001609382,0.000107306,0.000178995,0.000001117494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000127126,"about_ca_system_score_gemma":0.0001054672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000149606,"about_ca_topic_score_gemma":0.0001297876,"domain_scores_codex":[0.9981077,0.0002521132,0.0003942355,0.0003908733,0.0001126735,0.0007423488],"domain_scores_gemma":[0.9985405,0.0004697838,0.0002818605,0.000441178,0.0002292049,0.00003747215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8318501,0.0006564675,0.0248754,0.0001543795,0.0009458724,0.000002642688,0.0001370805,0.0001729624,0.1350079,0.00009789249,0.001353475,0.004745799],"study_design_scores_gemma":[0.8986936,0.002339065,0.001079494,0.00007276067,0.0003482678,0.000001463162,0.0003042946,0.0007178326,0.08755518,0.0001554437,0.008488156,0.000244411],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899669,0.005929449,0.00006223193,0.001295235,0.0003209892,0.002130124,0.00005903226,0.00001468983,0.000221334],"genre_scores_gemma":[0.9948662,0.003104385,0.00005268697,0.0005501874,0.0002460679,0.0005292487,0.0004803565,0.00002779974,0.0001430741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06684354,"threshold_uncertainty_score":0.5726065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01903826276283652,"score_gpt":0.2832448740454684,"score_spread":0.2642066112826318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}