{"id":"W3134855792","doi":"10.1182/blood.2020008654","title":"AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Chronic lymphocytic leukemia; Cancer research; Biology; Mutation; Gene; Somatic hypermutation; Leukemia; Cytidine deaminase; Activation-induced (cytidine) deaminase; Cancer; Lymphoma; Point mutation; Immunology; B cell; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002385208,0.0006502867,0.0002461366,0.001149014,0.0002599796,0.0004882479,0.0002989621,0.0006219231,0.002143385],"category_scores_gemma":[0.0001447167,0.000317537,0.0002983507,0.0003215576,0.0004428614,0.0002508575,0.0003849783,0.0007354429,0.0005373514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007021493,"about_ca_system_score_gemma":0.0002911282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039327,"about_ca_topic_score_gemma":0.001573272,"domain_scores_codex":[0.9996338,0.00006604459,0.00004363295,0.00007049135,0.00007710578,0.0001089802],"domain_scores_gemma":[0.9995116,0.00007978145,0.0001585681,0.00004532949,0.00002063199,0.0001840807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001707808,0.00008960789,0.0003659069,0.00002610966,0.000007312519,0.00015158,0.00004130512,0.0002258888,0.997674,0.0004405198,0.00005183787,0.0007551726],"study_design_scores_gemma":[0.00006488597,0.0006128532,0.004678177,0.00001986033,0.00002605879,0.0006556055,0.00006861951,0.001554883,0.9887735,0.0001902578,0.003343874,0.00001148518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940888,0.0007636133,0.002235347,0.00009019604,0.00002128991,0.0000564805,0.0008221646,0.0003423278,0.00157979],"genre_scores_gemma":[0.9924177,0.000554733,0.002692474,0.00005500343,0.0000121249,0.00007244648,0.0006468456,0.00006620023,0.003482499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002143385,"threshold_uncertainty_score":0.00717032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698113262165302,"score_gpt":0.3212620511073532,"score_spread":0.2942809184857002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}