{"id":"W3134855792","doi":"10.1182/blood.2020008654","title":"AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Chronic lymphocytic leukemia; Cancer research; Biology; Mutation; Gene; Somatic hypermutation; Leukemia; Cytidine deaminase; Activation-induced (cytidine) deaminase; Cancer; Lymphoma; Point mutation; Immunology; B cell; Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182013,0.0001876522,0.0003136795,0.0001121851,0.0001923531,0.00005962815,0.0001168661,0.000126278,0.000525649],"category_scores_gemma":[0.0003560961,0.0001670477,0.00007894121,0.0002708968,0.0001024121,0.00008647825,0.0002986064,0.000245796,0.0001750808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008157186,"about_ca_system_score_gemma":0.001786736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00032395,"about_ca_topic_score_gemma":0.0001182373,"domain_scores_codex":[0.9983299,0.00006429254,0.0002394988,0.0004578601,0.0004974724,0.0004109448],"domain_scores_gemma":[0.9987085,0.0001475616,0.00008754689,0.0005582479,0.0001745527,0.0003235396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004407567,0.002322529,0.01297848,0.000655394,0.0003584267,0.0068153,0.002450812,0.00001113992,0.9676155,0.0003452282,0.003490965,0.002515496],"study_design_scores_gemma":[0.05774614,0.0006072858,0.02439034,0.001771351,0.0002966709,0.003823722,0.0005636425,0.0001686752,0.9040393,0.0001848513,0.00602294,0.0003851106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942727,0.001254023,0.00001361501,0.0007262513,0.0000648238,0.0004126914,0.00002671413,0.00006768773,0.00316149],"genre_scores_gemma":[0.9904444,0.00009783236,0.002938919,0.0003729273,0.0001071657,0.00005922294,0.0001236802,0.00004046837,0.005815356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06357621,"threshold_uncertainty_score":0.6812009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698113262165302,"score_gpt":0.3212620511073532,"score_spread":0.2942809184857002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}