{"id":"W3134877629","doi":"10.1177/1534735421990078","title":"Current Advancements and Novel Strategies in the Treatment of Metastatic Melanoma","year":2021,"lang":"en","type":"review","venue":"Integrative Cancer Therapies","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"","keywords":"Medicine; Melanoma; Ipilimumab; Vemurafenib; Cancer; Oncology; Radiation therapy; Targeted therapy; Clinical trial; Skin cancer; Internal medicine; Intensive care medicine; Metastatic melanoma; Immunotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000460005,0.0006776752,0.0008840094,0.001886423,0.0002873076,0.0007997025,0.0007280261,0.00078597,0.004182522],"category_scores_gemma":[0.0004439989,0.000218095,0.000565921,0.001319539,0.0003847268,0.001179818,0.0005359831,0.002067771,0.001818564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005102818,"about_ca_system_score_gemma":0.000793125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006762101,"about_ca_topic_score_gemma":0.001664674,"domain_scores_codex":[0.9998405,0.000028328,0.00002167054,0.00003169899,0.00005915277,0.00001862734],"domain_scores_gemma":[0.9998555,0.00006501072,0.00001974042,0.000005455337,0.00003870803,0.00001552595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009259133,0.0001429605,0.0001466315,0.02079496,0.0000746741,0.0002719454,0.00008910266,0.000549392,0.005354168,0.006226595,0.01849091,0.9477661],"study_design_scores_gemma":[0.00001886995,0.0001674235,0.0005767745,0.002679229,0.00009680093,0.001170095,0.0000622226,0.0001264375,0.001090803,0.002397396,0.9915968,0.00001729402],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001761968,0.997758,0.0002189597,0.0002675864,0.0001783683,0.000007472443,0.0000205088,0.00001084817,0.001362093],"genre_scores_gemma":[0.0008702783,0.9979866,0.0002777662,0.0001666827,0.0001112829,0.0000080236,0.00003075303,0.000001675176,0.0005470483],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004182522,"threshold_uncertainty_score":0.01399189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07854031110835175,"score_gpt":0.3955977993313937,"score_spread":0.317057488223042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}