{"id":"W3134877629","doi":"10.1177/1534735421990078","title":"Current Advancements and Novel Strategies in the Treatment of Metastatic Melanoma","year":2021,"lang":"en","type":"review","venue":"Integrative Cancer Therapies","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"","keywords":"Medicine; Melanoma; Ipilimumab; Vemurafenib; Cancer; Oncology; Radiation therapy; Targeted therapy; Clinical trial; Skin cancer; Internal medicine; Intensive care medicine; Metastatic melanoma; Immunotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000784334,0.0003471008,0.0008281949,0.00005615189,0.00003000689,0.00003047525,0.0001651552,0.00007124947,0.00002167219],"category_scores_gemma":[0.00001011715,0.0001766878,0.0002094166,0.0001118907,0.000122592,0.000004829939,0.00002231339,0.00009342725,5.028739e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004108578,"about_ca_system_score_gemma":0.0003398581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007046146,"about_ca_topic_score_gemma":0.0004763936,"domain_scores_codex":[0.9989051,0.0001956131,0.0003234289,0.0003244531,0.000100536,0.0001508599],"domain_scores_gemma":[0.9993827,0.00005821225,0.0002116213,0.0002551968,0.00007068724,0.00002154546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001448997,0.0002561705,0.00002187213,0.000959777,0.0005536139,0.000003972251,0.001822413,6.523358e-7,0.0005327398,0.001710263,0.00006025282,0.9940638],"study_design_scores_gemma":[0.0003501547,0.0006050522,0.00001197388,0.002235036,0.0002087163,0.000008199062,0.002563351,4.40531e-7,0.0005751094,0.00008969596,0.993178,0.0001743375],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001467353,0.9968488,0.0003907745,0.00001393433,0.0001901848,0.0005475119,0.0004197961,0.00000198927,0.0001196069],"genre_scores_gemma":[0.0006734603,0.9979618,0.0001430555,0.00001448576,0.00009388745,0.0007189866,0.0002948416,0.00001844241,0.0000810252],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9938895,"threshold_uncertainty_score":0.7205119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07854031110835175,"score_gpt":0.3955977993313937,"score_spread":0.317057488223042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}