{"id":"W3134926617","doi":"10.1093/jcag/gwab002.188","title":"A190 ATP-INDUCED INFLAMMASOME ACTIVATION GENERATES MITOCHONDRIAL ROS PRODUCTION IN MACROPHAGES","year":2021,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Inflammasome; Mitochondrial ROS; Proinflammatory cytokine; Reactive oxygen species; Extracellular; Pyroptosis; Secretion; Mitochondrion; Citrobacter rodentium; Microbiology; Cell biology; Biology; Activator (genetics); Inflammation; Chemistry; Biochemistry; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094886,0.0003043631,0.0002515674,0.0002130624,0.0001498917,0.0003043312,0.0001355178,0.0003600434,0.001984009],"category_scores_gemma":[0.0001345403,0.0001142676,0.0002883149,0.0001425438,0.0001649578,0.0002924917,0.0002720571,0.0004687928,0.0006872185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001315139,"about_ca_system_score_gemma":0.0001252949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001190497,"about_ca_topic_score_gemma":0.00008590115,"domain_scores_codex":[0.9997897,0.00003552729,0.00003608332,0.00003993595,0.00005171045,0.00004702164],"domain_scores_gemma":[0.9999086,0.00001348828,0.0000249624,0.00001184493,0.00001934404,0.00002187752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003057619,0.00005133649,0.0003927459,0.00008274878,0.000006381181,0.000123675,0.00001574836,0.00002612634,0.997768,0.00004905323,0.00008517213,0.001093239],"study_design_scores_gemma":[0.0001262429,0.001445053,0.01628217,0.00003288742,0.00003442824,0.001152313,0.0001679555,0.001176459,0.9748768,0.0002463294,0.004448026,0.00001145941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893673,0.003258038,0.004295699,0.0003085117,0.0001405429,0.00004788585,0.0007883793,0.00007317628,0.001720404],"genre_scores_gemma":[0.9944347,0.001181458,0.001685951,0.0001602205,0.00007542969,0.00009415457,0.0007456879,0.00001061202,0.001611914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001984009,"threshold_uncertainty_score":0.006637156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005542062700438738,"score_gpt":0.2076925853427575,"score_spread":0.2021505226423188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}