{"id":"W3134930933","doi":"10.1002/jsp2.1143","title":"Inorganic polyphosphates stimulates matrix production in human annulus fibrosus cells","year":2021,"lang":"en","type":"article","venue":"JOR Spine","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute on Aging; National Institutes of Health; Arthritis Society; Foundation for the National Institutes of Health","keywords":"Aggrecan; Extracellular matrix; Proteoglycan; Matrix metalloproteinase; Cell biology; Chemistry; Glycosaminoglycan; Anabolism; Intervertebral disc; Matrix (chemical analysis); Cell culture; Matrix Metalloproteinase 3; Biochemistry; Anatomy; Biology; Pathology; Medicine; Genetics; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693358,0.0002445572,0.0004426261,0.0001771177,0.000121885,0.00004736548,0.00008419501,0.0001391409,0.000815773],"category_scores_gemma":[0.0001976153,0.0002372599,0.0001287496,0.0007236429,0.00006225982,0.000187606,0.00007061879,0.0002000586,0.00009818903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001231786,"about_ca_system_score_gemma":0.0001532597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003357532,"about_ca_topic_score_gemma":0.0001760141,"domain_scores_codex":[0.9982505,0.00003538898,0.000524114,0.0005019506,0.0002870212,0.0004010627],"domain_scores_gemma":[0.9990565,0.00002895499,0.0001279341,0.0004488435,0.0001851339,0.0001526063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001008571,0.0005812633,0.09265532,0.0002938194,0.00007356363,0.0002775976,0.0007408169,0.000424618,0.8970093,0.0004458089,0.002971095,0.004425992],"study_design_scores_gemma":[0.001770825,0.0002463361,0.2562161,0.0002420072,0.00007884752,0.0000788854,0.0001631969,0.000562032,0.7369415,0.0003245691,0.003116959,0.0002588224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880443,0.007671824,0.00002754001,0.002702302,0.0007101415,0.0003782075,0.000007236259,0.0001564385,0.0003020488],"genre_scores_gemma":[0.9753476,0.0001775623,0.00148081,0.0002324275,0.0006799494,0.00001248359,0.0001401665,0.00005166397,0.02187734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1635607,"threshold_uncertainty_score":0.9675177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229314949463209,"score_gpt":0.2908929794371528,"score_spread":0.2785998299425207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}