{"id":"W3134932213","doi":"10.1002/advs.202004632","title":"Construction of an Alternative NAD <sup>+</sup> De Novo Biosynthesis Pathway","year":2021,"lang":"en","type":"article","venue":"Advanced Science","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University","funders":"National Natural Science Foundation of China","keywords":"NAD+ kinase; Nicotinamide adenine dinucleotide; Cofactor; Biosynthesis; Biochemistry; Nicotinamide phosphoribosyltransferase; De novo synthesis; Chemistry; Amino acid; Metabolic pathway; Bioconversion; Enzyme; Biology; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001841484,0.0005183889,0.0003245222,0.000278868,0.0002572251,0.0004866299,0.0004594572,0.0004276013,0.0009388108],"category_scores_gemma":[0.0001517385,0.0001986585,0.000424172,0.0004410744,0.0001969208,0.00030256,0.0006691145,0.0006904973,0.0006797172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004929136,"about_ca_system_score_gemma":0.0005622327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102332,"about_ca_topic_score_gemma":0.0008905441,"domain_scores_codex":[0.9997905,0.00002907287,0.00001903876,0.00006407842,0.00004940917,0.00004783205],"domain_scores_gemma":[0.9998891,0.00001123682,0.00002421342,0.00001986624,0.00001996359,0.00003564445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008259599,0.00004195117,0.0002424628,0.00008360421,0.00001133808,0.0001282949,0.00002075628,0.0003305069,0.9923921,0.0008662155,0.00008898052,0.005711227],"study_design_scores_gemma":[0.00002374629,0.0001925626,0.0008459415,0.000009646593,0.00002187194,0.0002514432,0.00002249429,0.002811328,0.9839827,0.0002543615,0.01156667,0.00001737336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9077486,0.00114735,0.08047217,0.0002846189,0.0002239005,0.0002502977,0.001324877,0.000822794,0.007725371],"genre_scores_gemma":[0.9048606,0.000936135,0.08456146,0.00005478843,0.000009093393,0.0001382896,0.002548963,0.0001084546,0.0067822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102332,"threshold_uncertainty_score":0.003576398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007428395648995754,"score_gpt":0.2537636786352996,"score_spread":0.2463352829863038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}