{"id":"W3134947311","doi":"10.1007/s13311-021-01017-6","title":"Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation","year":2021,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Simon Fraser University; Montreal Neurological Institute and Hospital","funders":"Canada First Research Excellence Fund; Simon Fraser University; W. Garfield Weston Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Weston Brain Institute; McGill University","keywords":"Substantia nigra; Alpha-synuclein; Neuroscience; Dopamine; Striatum; Parkinson's disease; Neurology; Neuron; Pathology; Amyloid (mycology); Chemistry; Biology; Dopaminergic; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385098,0.0006890174,0.0006551192,0.0004471383,0.0002884708,0.0004574014,0.0003882702,0.0006942783,0.001613802],"category_scores_gemma":[0.00009007916,0.0002384801,0.0004167292,0.0003043042,0.0003906273,0.0005555093,0.0001332085,0.001551001,0.0005469105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005959754,"about_ca_system_score_gemma":0.0004696478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002193498,"about_ca_topic_score_gemma":0.003897079,"domain_scores_codex":[0.9998075,0.00001478607,0.00001641698,0.00004041058,0.00004666496,0.0000740722],"domain_scores_gemma":[0.9999202,0.000006999335,0.00002442491,0.000006524347,0.000009390214,0.00003240654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006272786,0.0002179187,0.000105559,0.00006325856,0.00002478354,0.00008984726,0.00001608593,0.0001564312,0.9957829,0.0002160403,0.0002449414,0.002454999],"study_design_scores_gemma":[0.00007778063,0.0009435951,0.00195638,0.00001044947,0.00005686131,0.0002444168,0.0000324391,0.0016339,0.9933981,0.0001147256,0.001523466,0.000007958039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897789,0.003422848,0.002658956,0.0004272418,0.0001692031,0.00004231836,0.0007950862,0.0003488546,0.002356514],"genre_scores_gemma":[0.9911625,0.002501426,0.001940355,0.00009474465,0.00002093205,0.00003477098,0.0006134874,0.00003174217,0.003600044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002193498,"threshold_uncertainty_score":0.005398691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0389611923069449,"score_gpt":0.2955394255069131,"score_spread":0.2565782331999683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}