{"id":"W3134948809","doi":"10.1186/s13195-021-00793-9","title":"Development of a novel, sensitive translational immunoassay to detect plasma glial fibrillary acidic protein (GFAP) after murine traumatic brain injury","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; International Collaboration On Repair Discoveries; University of British Columbia","funders":"Weston Brain Institute","keywords":"Glial fibrillary acidic protein; Immunoassay; Traumatic brain injury; Biomarker; Detection limit; Medicine; Pathology; Chemistry; Immunology; Biochemistry; Chromatography; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028848,0.0008800702,0.0003668381,0.0006661777,0.0001781493,0.0003565161,0.0005145437,0.0006024652,0.0004510429],"category_scores_gemma":[0.00071578,0.0002598847,0.0004691417,0.0002129838,0.0003571228,0.0002328699,0.0003066924,0.0009708026,0.0004032024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003292713,"about_ca_system_score_gemma":0.0003928767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000304359,"about_ca_topic_score_gemma":0.000579258,"domain_scores_codex":[0.999249,0.000121771,0.00005148727,0.0001933543,0.0003106546,0.0000736672],"domain_scores_gemma":[0.9993504,0.00009171251,0.0002059337,0.00006554949,0.0002224509,0.00006391195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004744836,0.00004378111,0.0003550657,0.00003775572,0.000007878747,0.00002186015,0.00001322528,0.0001160757,0.9965244,0.00005489386,0.00006706842,0.002710616],"study_design_scores_gemma":[0.00001588308,0.000776445,0.002133281,0.00001198803,0.00002932785,0.0001940316,0.00001407834,0.003140178,0.991823,0.00008183268,0.001766543,0.00001345181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5996547,0.002847442,0.391232,0.0004307371,0.0002987886,0.0006784693,0.00102866,0.001497098,0.002332055],"genre_scores_gemma":[0.7775903,0.001802455,0.2139468,0.0004942077,0.0001016638,0.001005555,0.001248809,0.00009927012,0.003711007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028848,"threshold_uncertainty_score":0.005441129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07194597086601924,"score_gpt":0.3572457405674613,"score_spread":0.2852997697014421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}