{"id":"W3134953187","doi":"10.1007/s13555-021-00504-0","title":"Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study","year":2021,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Boehringer Ingelheim","keywords":"Palmoplantar pustulosis; Medicine; Placebo; Clinical endpoint; Internal medicine; Gastroenterology; Psoriasis Area and Severity Index; Multicenter trial; Placebo-controlled study; Intention-to-treat analysis; Randomized controlled trial; Surgery; Double blind; Immunology; Multicenter study; Psoriasis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004307129,0.001280372,0.002266069,0.0003448519,0.0003342888,0.0007939579,0.0006017086,0.0012571,0.002342272],"category_scores_gemma":[0.002460934,0.0005792881,0.002191784,0.0003844256,0.0009025817,0.0009254951,0.0002700311,0.001832867,0.0004245931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000349192,"about_ca_system_score_gemma":0.001020339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002441066,"about_ca_topic_score_gemma":0.0003498986,"domain_scores_codex":[0.9987935,0.0007370191,0.0001124164,0.0001410418,0.0001118792,0.0001040542],"domain_scores_gemma":[0.9980891,0.0006566297,0.000525812,0.0001462854,0.0001714594,0.0004107299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8832483,0.0299951,0.004068991,0.001323372,0.002128768,0.0001748204,0.0001801864,0.0007989857,0.02197932,0.00008489547,0.000793605,0.05522352],"study_design_scores_gemma":[0.646049,0.3433552,0.007179803,0.00004359823,0.0008883896,0.000149261,0.00003152887,0.0004272866,0.001308014,0.00006984574,0.0004809512,0.00001716377],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904237,0.005611761,0.0008039314,0.0003359153,0.0001459075,0.001650204,0.0003342181,0.00006184751,0.0006324276],"genre_scores_gemma":[0.9934338,0.002560694,0.001209548,0.0004298837,0.0002627155,0.001212615,0.0004550204,0.00001116451,0.0004245264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004307129,"threshold_uncertainty_score":0.02277857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211709192181169,"score_gpt":0.2831314459354729,"score_spread":0.261960526717356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}