{"id":"W3134953187","doi":"10.1007/s13555-021-00504-0","title":"Spesolimab, an Anti-Interleukin-36 Receptor Antibody, in Patients with Palmoplantar Pustulosis: Results of a Phase IIa, Multicenter, Double-Blind, Randomized, Placebo-Controlled Pilot Study","year":2021,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Boehringer Ingelheim","keywords":"Palmoplantar pustulosis; Medicine; Placebo; Clinical endpoint; Internal medicine; Gastroenterology; Psoriasis Area and Severity Index; Multicenter trial; Placebo-controlled study; Intention-to-treat analysis; Randomized controlled trial; Surgery; Double blind; Immunology; Multicenter study; Psoriasis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004449945,0.0004051304,0.001737471,0.0002622606,0.0001550034,0.00002060526,0.0001918303,0.0002114942,0.0001202247],"category_scores_gemma":[0.00004012353,0.0002628916,0.0001225694,0.0001934196,0.0002970498,0.0001616959,0.00004676998,0.0002234007,0.00002343005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001691069,"about_ca_system_score_gemma":0.00006971257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001879017,"about_ca_topic_score_gemma":0.0002806343,"domain_scores_codex":[0.9963755,0.001653862,0.0008609135,0.0006073368,0.00006993374,0.0004324305],"domain_scores_gemma":[0.9984637,0.0005111119,0.0003888208,0.0004280528,0.0001584298,0.0000498119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8484531,0.0145427,0.1234175,0.00001670148,0.002425976,0.0001347294,0.002076642,8.543955e-7,0.006518432,0.00002972625,0.00002516709,0.002358438],"study_design_scores_gemma":[0.9570782,0.003183455,0.01356767,0.00006169001,0.0003546064,0.00008710238,0.0006541554,0.000006891272,0.02443306,0.00000971768,0.0002724348,0.0002910006],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921109,0.00430147,0.000009125676,0.000144111,0.0004705981,0.002674454,0.0001418058,0.00004074853,0.0001067668],"genre_scores_gemma":[0.9962878,0.00208169,0.00005257238,0.00009545582,0.00001728408,0.0002275387,0.001104951,0.00002648507,0.0001062633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1098499,"threshold_uncertainty_score":0.9999824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211709192181169,"score_gpt":0.2831314459354729,"score_spread":0.261960526717356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}