{"id":"W3134963806","doi":"10.1016/j.jacc.2020.12.058","title":"Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis","year":2021,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":228,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Novartis","keywords":"Medicine; Familial hypercholesterolemia; PCSK9; Placebo; Internal medicine; Statin; Endocrinology; Atherosclerotic cardiovascular disease; Cholesterol; Lipoprotein; Dosing; Randomization; Gastroenterology; Clinical trial; Disease; LDL receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002021684,0.0001629271,0.003819684,0.0004133233,0.00003264167,0.0000028085,0.0002009602,0.00007819451,0.00001182095],"category_scores_gemma":[0.001301595,0.00008579201,0.001573523,0.001943196,0.0002777187,0.00004490897,0.0000899668,0.0002913204,1.831889e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001394746,"about_ca_system_score_gemma":0.0007023248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009453924,"about_ca_topic_score_gemma":0.00007376935,"domain_scores_codex":[0.9954901,0.001882318,0.00149088,0.0001843595,0.0007335551,0.0002187869],"domain_scores_gemma":[0.9963053,0.0003588072,0.001800066,0.0006049552,0.0008235195,0.0001073157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007163323,0.000248383,0.9654224,0.00005559368,0.01148219,0.00009425884,0.0001487008,0.001317175,0.003090811,0.00000678369,0.0001623247,0.01080804],"study_design_scores_gemma":[0.005742158,0.002868509,0.9833505,0.0001702161,0.005250118,0.00009736598,0.0007899918,0.0000097456,0.001262524,0.000005798845,0.0003684539,0.00008468309],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984171,0.0001647942,0.0001982477,0.0003430755,0.0001640065,0.0003447327,0.0002967871,0.000001998824,0.00006921299],"genre_scores_gemma":[0.9983047,0.0001612095,0.0010032,0.0003592026,0.0001229417,0.000004761415,0.000005623991,0.00001728463,0.00002110771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01792802,"threshold_uncertainty_score":0.3498496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03411595838465424,"score_gpt":0.2873321607598456,"score_spread":0.2532162023751914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}