{"id":"W3134967846","doi":"10.2139/ssrn.3581364","title":"Release of Motor Neuron Exosomes Containing TDP-43 and mTNF-α Near the Neuromuscular Junction Induces Skeletal Muscle Atrophy and Reduced Contractility in a 3D Human Model of ALS","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Contractility; Neuromuscular junction; Motor neuron; Medicine; Atrophy; Skeletal muscle; Muscle atrophy; Amyotrophic lateral sclerosis; Neuroscience; Cardiology; Anatomy; Internal medicine; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003729689,0.0003085304,0.0005568572,0.0002764429,0.0003642055,0.0004699807,0.0002629551,0.0008264139,0.0009653874],"category_scores_gemma":[0.0001581238,0.0002215873,0.000705837,0.0001700158,0.0004417049,0.0003823364,0.0003191844,0.0009107526,0.0003501656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462452,"about_ca_system_score_gemma":0.0003699853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008081452,"about_ca_topic_score_gemma":0.001149989,"domain_scores_codex":[0.9996448,0.00005805628,0.00003424041,0.00008757547,0.0001101895,0.00006522583],"domain_scores_gemma":[0.9998643,0.00002472681,0.00004132945,0.00001710047,0.00001123899,0.00004125966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008491063,0.0001678514,0.0002089242,0.00006343258,0.00002812233,0.0002995673,0.00006072796,0.0002287144,0.9968134,0.0001257937,0.0001201702,0.001034074],"study_design_scores_gemma":[0.0001545025,0.00160145,0.006262643,0.00001970769,0.000080753,0.0006448025,0.0001624617,0.002832014,0.9866345,0.0001170813,0.001475264,0.00001475701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966042,0.0005207889,0.001650143,0.000118552,0.00009113704,0.00002767644,0.0003689459,0.00005038872,0.0005681128],"genre_scores_gemma":[0.9940926,0.0004275153,0.002033217,0.00006824313,0.00001455488,0.00006664162,0.0005100418,0.00002197937,0.002765142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009653874,"threshold_uncertainty_score":0.003229558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03138612828513018,"score_gpt":0.2810875536153832,"score_spread":0.2497014253302531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}