{"id":"W3134994882","doi":"10.1111/hae.14292","title":"Pharmacokinetic implications of dosing emicizumab based on vial size: A simulation study","year":2021,"lang":"en","type":"article","venue":"Haemophilia","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; McMaster University; University of Waterloo","funders":"","keywords":"Vial; Dosing; Medicine; Pharmacokinetics; Regimen; Nuclear medicine; Pharmacology; Surgery; Chromatography; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001271553,0.000615998,0.0007105536,0.0003892651,0.0002895222,0.0008218286,0.0008335864,0.001304127,0.002380784],"category_scores_gemma":[0.005114287,0.0003506847,0.001241152,0.0004318447,0.0003523469,0.0005292587,0.0004766397,0.001093323,0.0001637825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001592325,"about_ca_system_score_gemma":0.001410683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01889539,"about_ca_topic_score_gemma":0.008933584,"domain_scores_codex":[0.9995599,0.0002381102,0.00001650259,0.00004736586,0.00005962346,0.00007860463],"domain_scores_gemma":[0.994373,0.004493772,0.000438161,0.0001086887,0.00044114,0.0001453259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002737423,0.0001782657,0.005293858,0.00004480118,0.00005206766,0.0001273404,0.00002434416,0.9905673,0.0005258702,0.0005578698,0.0003743281,0.001980266],"study_design_scores_gemma":[0.0001368253,0.0003831496,0.002448261,0.00001678526,0.00007580304,0.00006308925,0.0000389371,0.9953734,0.000554675,0.0004610442,0.0004351666,0.00001292417],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833213,0.0003361276,0.01076046,0.00038464,0.00002745711,0.0001100151,0.0005924024,0.00004671962,0.0044209],"genre_scores_gemma":[0.9941048,0.0001811941,0.004264769,0.00008387645,0.000006928352,0.00007356834,0.0002795301,0.00001026003,0.0009951807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01889539,"threshold_uncertainty_score":0.03757083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07041949286454836,"score_gpt":0.429097122988103,"score_spread":0.3586776301235546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}