{"id":"W3135019275","doi":"10.1080/17425247.2021.1902984","title":"Exploring the transformability of polymer-lipid hybrid nanoparticles and nanomaterial-biology interplay to facilitate tumor penetration, cellular uptake and intracellular targeting of anticancer drugs","year":2021,"lang":"en","type":"article","venue":"Expert Opinion on Drug Delivery","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Nanocarriers; Intracellular; Doxorubicin; Liposome; Drug delivery; Cancer cell; Biophysics; Drug carrier; Penetration (warfare); Chemistry; Cell biology; Nanotechnology; Biology; Biochemistry; Materials science; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010795,0.0002681459,0.0001076068,0.0001541107,0.0000700708,0.0002689373,0.0001225994,0.0003085674,0.0006972087],"category_scores_gemma":[0.0001996004,0.00009266973,0.0002146154,0.00007895954,0.0001905386,0.0003665612,0.0001800929,0.0002695693,0.0001934209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003334326,"about_ca_system_score_gemma":0.0001699596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002436932,"about_ca_topic_score_gemma":0.0003928544,"domain_scores_codex":[0.9999361,0.000009872439,0.000003450363,0.00001690475,0.00002143316,0.00001217009],"domain_scores_gemma":[0.9999278,0.00002698161,0.0000207927,0.000006629352,0.00001151504,0.000006376043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002492289,0.00002217891,0.0001719599,0.00006761094,0.00000447448,0.00003628809,0.00001232008,0.0004021672,0.9956143,0.0003577499,0.00002896609,0.003256958],"study_design_scores_gemma":[0.000006140656,0.0002276233,0.0009766853,0.000006760187,0.00001255854,0.0001228821,0.00001076396,0.002648604,0.9931788,0.0001423899,0.002661752,0.000005003547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9686575,0.004297507,0.0221913,0.000247648,0.00002552377,0.0001062621,0.0001549892,0.00008805304,0.004231198],"genre_scores_gemma":[0.9872214,0.001893518,0.009489678,0.00005894731,0.000007346231,0.00005086133,0.0001138509,0.00001442564,0.001150068],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0006972087,"threshold_uncertainty_score":0.002419233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03286906522931523,"score_gpt":0.2538348694216907,"score_spread":0.2209658041923755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}