{"id":"W3135035550","doi":"10.1007/s12192-021-01199-0","title":"Isoflurane and low-level carbon monoxide exposures increase expression of pro-survival miRNA in neonatal mouse heart","year":2021,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada","keywords":"Cardioprotection; Isoflurane; Ischemic preconditioning; Ischemia; microRNA; Medicine; Autophagy; Apoptosis; Programmed cell death; Downregulation and upregulation; Oxidative stress; Reperfusion injury; Pharmacology; Anesthesia; Internal medicine; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008047475,0.0001788723,0.000238302,0.00003397882,0.00003728956,0.00001876784,0.0000734237,0.0001464174,0.0000109382],"category_scores_gemma":[0.00002700045,0.0001661592,0.00004479305,0.00004859703,0.00008628509,0.000006578367,0.0001588725,0.00008272377,2.551974e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004441854,"about_ca_system_score_gemma":0.00004921641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003060533,"about_ca_topic_score_gemma":0.0003400611,"domain_scores_codex":[0.9989725,0.00007542086,0.0002325474,0.0003814525,0.0001216052,0.0002165174],"domain_scores_gemma":[0.999518,0.00001753776,0.00005664873,0.0002370053,0.00004768412,0.0001230718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001092325,0.00008813959,0.02304241,0.0001719664,0.000008310757,0.00002152299,0.0002003926,0.000009852987,0.9753947,0.000006475122,0.00002404245,0.0009229236],"study_design_scores_gemma":[0.0009209212,0.0001005608,0.01353209,0.00007873821,0.000009020945,0.000008648291,0.001040505,0.0000544802,0.9836416,0.0000115263,0.0004119209,0.0001899991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904695,0.009014188,0.00001146598,0.00005046824,0.0000461251,0.0001071826,0.0000747294,0.000006163038,0.0002201813],"genre_scores_gemma":[0.9975513,0.001606695,0.0001785544,0.00004343638,0.00006984429,0.00001967749,0.00008879234,0.00002068952,0.0004210723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009510321,"threshold_uncertainty_score":0.6775777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00961958909745247,"score_gpt":0.2152041396677163,"score_spread":0.2055845505702639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}