{"id":"W3135058903","doi":"10.15252/embj.2019103811","title":"A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins","year":2021,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Uppsala Universitet; Medizinische Universität Wien; Universität Wien; University of Wollongong; Durham University; Max-Planck-Institut für Terrestrische Mikrobiologie; Association Belge contre les Maladies Neuro-Musculaires","keywords":"Biology; Hsp27; Chaperone (clinical); Heat shock protein; Mutation; Genetics; Biochemistry; Molecular biology; Gene; Hsp70; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077877,0.0006112942,0.0003260458,0.0002113881,0.0002386896,0.0001589227,0.0002981605,0.0004919819,0.002186569],"category_scores_gemma":[0.000224557,0.0001604849,0.0004073014,0.0001543869,0.0003613721,0.0001247345,0.0003170149,0.000548652,0.0006677961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003052476,"about_ca_system_score_gemma":0.0001643347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001150009,"about_ca_topic_score_gemma":0.0007492194,"domain_scores_codex":[0.9998913,0.00002592329,0.00001137661,0.00002671096,0.00002358262,0.00002116098],"domain_scores_gemma":[0.9998111,0.00002276881,0.00006815361,0.00001172228,0.00001594894,0.00007024821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003199966,0.00007765039,0.000618055,0.00003260838,0.00003156805,0.001990162,0.00003172296,0.0001570404,0.9955915,0.0001161971,0.0001528318,0.000880656],"study_design_scores_gemma":[0.0002012606,0.001109231,0.02968561,0.00002910488,0.0001038405,0.01332415,0.0001289845,0.004808532,0.9461332,0.0002755157,0.004147491,0.00005312794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980676,0.0001849126,0.0009935042,0.00007012684,0.00002571056,0.00001360332,0.0001717707,0.00004708287,0.0004256486],"genre_scores_gemma":[0.9984456,0.00007262078,0.0004422486,0.0000588303,0.00001145618,0.00001445694,0.0002081558,0.00003157602,0.0007152559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002186569,"threshold_uncertainty_score":0.007314801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235828224153002,"score_gpt":0.2940988767149565,"score_spread":0.2705160542996564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}