{"id":"W3135075565","doi":"10.1200/jco.2021.39.6_suppl.26","title":"Concordance of <i>BRCA1</i>, <i>BRCA2</i> (BRCA), and <i>ATM</i> mutations identified in matched tumor tissue and circulating tumor DNA (ctDNA) in men with metastatic castration-resistant prostate cancer (mCRPC) screened in the PROfound study.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Concordance; Olaparib; Enzalutamide; Internal medicine; Oncology; Cancer; Prostate cancer; Gene; Genetics; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001405023,0.000176168,0.0002340934,0.0005982011,0.0001719843,0.0004475784,0.0004016056,0.0002906745,0.001413332],"category_scores_gemma":[0.002878664,0.0002083828,0.0002608601,0.0003227511,0.0002997235,0.0002457766,0.0006019056,0.0003042453,0.0002249135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002093367,"about_ca_system_score_gemma":0.0001647876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001571702,"about_ca_topic_score_gemma":0.003579706,"domain_scores_codex":[0.9989787,0.0002614913,0.0001107678,0.0003585298,0.0002104378,0.00008007949],"domain_scores_gemma":[0.9980147,0.0006312911,0.0006979321,0.0002272978,0.0001837462,0.00024507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001700997,0.00004582154,0.990396,0.00003259009,0.0001254197,0.0001044525,0.0001364874,0.0001633472,0.002426692,0.00004370563,0.0003496532,0.004474694],"study_design_scores_gemma":[0.00007588098,0.0007758117,0.9957812,0.00001024539,0.0001035021,0.0008164594,0.0001061189,0.0004201719,0.001343273,0.00004724141,0.0005123502,0.000007745448],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984304,0.0002691364,0.00008272834,0.00001544656,0.000003028352,0.00001052472,0.0005529643,0.000005261345,0.0006304156],"genre_scores_gemma":[0.9992465,0.00002609953,0.00006909975,0.00002872542,0.000002791117,0.00000448402,0.0005377246,0.000001271157,0.00008336921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001571702,"threshold_uncertainty_score":0.007430494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04741719211577246,"score_gpt":0.390128650031131,"score_spread":0.3427114579153585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}