{"id":"W3135075565","doi":"10.1200/jco.2021.39.6_suppl.26","title":"Concordance of <i>BRCA1</i>, <i>BRCA2</i> (BRCA), and <i>ATM</i> mutations identified in matched tumor tissue and circulating tumor DNA (ctDNA) in men with metastatic castration-resistant prostate cancer (mCRPC) screened in the PROfound study.","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Concordance; Olaparib; Enzalutamide; Internal medicine; Oncology; Cancer; Prostate cancer; Gene; Genetics; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002125875,0.0001482612,0.0007602369,0.00007071203,0.00003730207,0.00003706825,0.0001390752,0.00006982431,0.000004541999],"category_scores_gemma":[0.001053323,0.0001122088,0.0000541304,0.0002485954,0.0002150819,0.00002057657,0.00007042391,0.0003404071,1.313485e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005176237,"about_ca_system_score_gemma":0.001553159,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005405673,"about_ca_topic_score_gemma":0.03718342,"domain_scores_codex":[0.9971108,0.000558607,0.00162075,0.000298513,0.000205751,0.0002055704],"domain_scores_gemma":[0.9976313,0.0008007514,0.001047285,0.0001769503,0.0002572919,0.00008640628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004441033,0.003364815,0.6982991,0.0002620432,0.0004465894,0.004130723,0.003798196,0.003356401,0.2710412,0.0002362303,0.0002281172,0.01039547],"study_design_scores_gemma":[0.01816553,0.005938317,0.9489338,0.0002771835,0.0002626112,0.0004207955,0.01189111,0.0002615295,0.01162154,0.0007232238,0.001199993,0.000304342],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962351,0.001868338,0.0000371471,0.001005077,0.00009481977,0.0005474486,0.00002906499,8.928481e-7,0.0001821512],"genre_scores_gemma":[0.9976059,0.0004717498,0.001103021,0.0006334225,0.00009085186,0.00004957131,0.000008822672,0.00001460659,0.00002205637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2594197,"threshold_uncertainty_score":0.9803855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04741719211577246,"score_gpt":0.390128650031131,"score_spread":0.3427114579153585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}