{"id":"W3135104880","doi":"10.1016/j.jbiotec.2021.02.016","title":"Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin","year":2021,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"Heart and Stroke Foundation of Canada","keywords":"Protease; Enteropeptidase; In vivo; Chemistry; Plasmin; Proteases; Biochemistry; Pharmacology; Biology; Recombinant DNA; Fusion protein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188482,0.0003952105,0.0001940225,0.0001862331,0.0001898817,0.0003759688,0.0003182919,0.0002625257,0.001012975],"category_scores_gemma":[0.0002784679,0.0001520738,0.0002367303,0.0002062397,0.0002001298,0.0001442493,0.0001417741,0.000643704,0.0003358326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000317596,"about_ca_system_score_gemma":0.000179207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000936282,"about_ca_topic_score_gemma":0.001042026,"domain_scores_codex":[0.9998236,0.00004230052,0.00002528697,0.00002849219,0.00004710551,0.00003321172],"domain_scores_gemma":[0.9998358,0.00005791728,0.00004397073,0.00002067828,0.00001430481,0.00002721859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007661375,0.00005896934,0.0001760073,0.00000806604,0.000006318211,0.00008134549,0.000013069,0.0002000817,0.9988984,0.0001014707,0.00003002287,0.0003496533],"study_design_scores_gemma":[0.00002934825,0.0002032744,0.002114891,0.000002724681,0.00002118194,0.0006481902,0.00002312313,0.001898654,0.9932707,0.00003300355,0.001749123,0.000005704914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954302,0.0003051191,0.002951997,0.00009032671,0.00003136791,0.00002888904,0.0004119573,0.00001951289,0.0007306995],"genre_scores_gemma":[0.994215,0.0002215193,0.002460344,0.00004407717,0.00001401957,0.00001998929,0.001320562,0.00003414942,0.001670379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001012975,"threshold_uncertainty_score":0.003388762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012607211347265,"score_gpt":0.2397978852164855,"score_spread":0.2271906738692205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}