{"id":"W3135104880","doi":"10.1016/j.jbiotec.2021.02.016","title":"Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin","year":2021,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"Heart and Stroke Foundation of Canada","keywords":"Protease; Enteropeptidase; In vivo; Chemistry; Plasmin; Proteases; Biochemistry; Pharmacology; Biology; Recombinant DNA; Fusion protein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000376053,0.0001596476,0.0006046061,0.0007772259,0.00003071523,0.00001217018,0.00004220729,0.0003535602,0.00001594679],"category_scores_gemma":[0.0003546221,0.0001458694,0.00005390481,0.0005767684,0.0001249086,0.0002060946,0.00005731648,0.0004032626,1.308975e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000711772,"about_ca_system_score_gemma":0.0002541826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003957966,"about_ca_topic_score_gemma":0.0000787821,"domain_scores_codex":[0.9984944,0.0001084184,0.0007906707,0.0002061658,0.0002045061,0.0001957705],"domain_scores_gemma":[0.9988638,0.00004954902,0.0007579281,0.0001010191,0.0001456656,0.00008200247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001489827,0.0002350298,0.0657016,0.0002474113,0.00002803571,0.0001123096,0.0006120825,0.000001511024,0.9280059,0.00005278186,0.000001572907,0.003511878],"study_design_scores_gemma":[0.003359031,0.0004367693,0.05667913,0.0009784516,0.00003239465,0.001067187,0.000387644,0.0003971734,0.9363194,0.000184997,0.00005125354,0.0001065698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972713,0.0002826986,0.0004122101,0.001443706,0.000053952,0.0004972899,0.00001910169,0.00001414687,0.000005603234],"genre_scores_gemma":[0.9976376,0.0001501256,0.002052018,0.00004339272,0.00006183123,0.000008781497,0.000006641932,0.00001767296,0.00002189142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009022465,"threshold_uncertainty_score":0.5948381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012607211347265,"score_gpt":0.2397978852164855,"score_spread":0.2271906738692205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}