{"id":"W3135106422","doi":"10.1016/j.jpba.2021.114013","title":"PAT solutions to monitor adsorption of Tetanus Toxoid with aluminum adjuvants","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Autodesk (Canada); Sanofi (Canada)","funders":"","keywords":"Chemistry; Adsorption; Toxoid; Aluminium; Particle size; Particle (ecology); Kinetics; Chromatography; Antigen; Organic chemistry; Physical chemistry; Immunization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003869281,0.00008802108,0.0002657327,0.000114107,0.00004075109,0.00001228698,0.000100083,0.00008478999,0.0001453527],"category_scores_gemma":[0.0001812539,0.00005942009,0.000174496,0.0005788094,0.0001827696,0.000005885352,0.00006543254,0.0001191984,0.000001502432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001180685,"about_ca_system_score_gemma":0.0000819019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000367681,"about_ca_topic_score_gemma":0.000009367574,"domain_scores_codex":[0.9988441,0.0001073741,0.0003937933,0.0001780205,0.0003200781,0.0001566066],"domain_scores_gemma":[0.9989625,0.00002280186,0.0001308924,0.0001372246,0.000375317,0.0003712708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002999119,0.0004846945,0.005118117,0.00002970104,0.0009001062,0.00001642781,0.00003305152,0.00001313099,0.957629,0.00002829676,0.0002266646,0.03522089],"study_design_scores_gemma":[0.002164844,0.001322514,0.05736493,0.00005475038,0.002632178,0.0002029634,0.0003883098,0.001073334,0.8489583,0.0001412622,0.08536437,0.0003323012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658874,0.002935357,0.02764901,0.003297972,0.00007435861,0.00006147206,0.0000448058,0.000002454875,0.00004717685],"genre_scores_gemma":[0.9970059,0.0005213072,0.001998307,0.0002052728,0.0001545532,0.000002427889,0.00002143077,0.000003611244,0.00008714124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1086708,"threshold_uncertainty_score":0.2423081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02192928288824326,"score_gpt":0.3129601036399652,"score_spread":0.2910308207517219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}