{"id":"W3135106607","doi":"10.1016/j.clim.2021.108713","title":"Tityus serrulatus scorpion venom as a potential drug source for Chagas' disease: Trypanocidal and immunomodulatory activity","year":2021,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Universidade Federal de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Trypanosoma cruzi; Parasitemia; Chagas disease; In vivo; Pharmacology; Nitric oxide; Biology; Cytokine; In vitro; p38 mitogen-activated protein kinases; Immune system; Chemistry; Immunology; Parasite hosting; Biochemistry; Plasmodium falciparum; MAPK/ERK pathway; Signal transduction; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001024946,0.0001595578,0.0001255318,0.000256107,0.0001983432,0.0002315634,0.00009804432,0.000201869,0.001035058],"category_scores_gemma":[0.00006686767,0.00003295931,0.0001065134,0.0001203414,0.0002024718,0.0001483779,0.0001708039,0.0001852537,0.00006715248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007927544,"about_ca_system_score_gemma":0.0001420268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003852625,"about_ca_topic_score_gemma":0.0007276426,"domain_scores_codex":[0.9999822,0.00000499371,0.000001234487,0.000002229333,0.000004608765,0.000004740212],"domain_scores_gemma":[0.9999782,0.00000460243,0.000006120322,0.000001151118,0.000003914975,0.000006056222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009189514,0.0002739534,0.009911084,0.0006747135,0.00005624519,0.001323791,0.0001703857,0.0001840528,0.9216144,0.00090506,0.0003143353,0.06365313],"study_design_scores_gemma":[0.0002462983,0.01412108,0.4215343,0.000580597,0.0008645988,0.01305286,0.00109837,0.00263583,0.5024791,0.00158866,0.04176586,0.00003247715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742705,0.02217726,0.0004978101,0.000408553,0.00003755752,0.00001870806,0.00004683694,0.00001071465,0.002532257],"genre_scores_gemma":[0.9900377,0.007902279,0.0006060292,0.00008013776,0.00004366753,0.000007407373,0.00004987663,0.000001592748,0.001271281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035058,"threshold_uncertainty_score":0.003462613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03464436752603253,"score_gpt":0.3810792688400038,"score_spread":0.3464349013139713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}