{"id":"W3135106607","doi":"10.1016/j.clim.2021.108713","title":"Tityus serrulatus scorpion venom as a potential drug source for Chagas' disease: Trypanocidal and immunomodulatory activity","year":2021,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Universidade Federal de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Trypanosoma cruzi; Parasitemia; Chagas disease; In vivo; Pharmacology; Nitric oxide; Biology; Cytokine; In vitro; p38 mitogen-activated protein kinases; Immune system; Chemistry; Immunology; Parasite hosting; Biochemistry; Plasmodium falciparum; MAPK/ERK pathway; Signal transduction; Malaria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008993654,0.0001781066,0.000497198,0.00007564818,0.0002494423,0.00004255906,0.0001462636,0.00023247,0.0002750399],"category_scores_gemma":[0.001676153,0.0001736127,0.0003050462,0.0001545795,0.0006253478,0.0001094675,0.0002806163,0.0006000899,0.0001232907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007326439,"about_ca_system_score_gemma":0.000868162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003659256,"about_ca_topic_score_gemma":0.00001242769,"domain_scores_codex":[0.998099,0.0002192536,0.0004341938,0.0005868868,0.0001718453,0.0004888088],"domain_scores_gemma":[0.9980712,0.0004231821,0.0001204161,0.0007446131,0.0002685545,0.0003720594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007117978,0.003320317,0.02700515,0.0002440902,0.001577326,0.0003689788,0.0001297962,0.000004465718,0.656712,0.004688207,0.006215626,0.2926161],"study_design_scores_gemma":[0.003488596,0.0005717552,0.9318199,0.00003872629,0.0001599585,0.0002069501,0.00007473738,0.0002398207,0.002083959,0.0008938398,0.06025426,0.0001674894],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856471,0.004790962,0.001461047,0.006543202,0.0005310609,0.0005653414,0.00006026261,0.00008585354,0.0003151622],"genre_scores_gemma":[0.9912727,0.0009780356,0.0004062638,0.0005852442,0.000436238,0.00008878134,0.0001365814,0.00003522378,0.00606092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9048148,"threshold_uncertainty_score":0.7079719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03464436752603253,"score_gpt":0.3810792688400038,"score_spread":0.3464349013139713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}