{"id":"W3135123677","doi":"10.1200/jco.2021.39.6_suppl.9","title":"Final results from ACIS, a randomized, placebo (PBO)-controlled double-blind phase 3 study of apalutamide (APA) and abiraterone acetate plus prednisone (AAP) versus AAP in patients (pts) with chemo-naive metastatic castration-resistant prostate cancer (mCRPC).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Janssen Research and Development","keywords":"Medicine; Abiraterone acetate; Prostate cancer; Clinical endpoint; Interim analysis; Internal medicine; Placebo; Progression-free survival; Androgen deprivation therapy; Prednisone; Mallinckrodt; Enzalutamide; Randomization; Randomized controlled trial; Gastroenterology; Urology; Oncology; Androgen receptor; Cancer; Chemotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002767556,0.001607756,0.002343898,0.0005124208,0.0006737483,0.001080648,0.001053029,0.001652787,0.01509457],"category_scores_gemma":[0.002674485,0.0006004765,0.001716937,0.0004130408,0.0007787996,0.0007499062,0.0003328847,0.002814387,0.001496929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006996985,"about_ca_system_score_gemma":0.002443043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008239124,"about_ca_topic_score_gemma":0.00261806,"domain_scores_codex":[0.9991361,0.0004479173,0.00007647079,0.0001135799,0.0001149371,0.0001109712],"domain_scores_gemma":[0.9985319,0.0003818175,0.0002943551,0.00008708849,0.0002390057,0.0004657332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9424424,0.0109408,0.001007962,0.001479385,0.001337255,0.00008483997,0.00007797228,0.0004270193,0.007768875,0.0003199259,0.005444682,0.02866882],"study_design_scores_gemma":[0.9207193,0.06966565,0.002882754,0.00007759623,0.0007293518,0.0000445167,0.00001574453,0.0001986122,0.001372181,0.0001932526,0.004085984,0.00001511083],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8555161,0.009236283,0.003436629,0.002809725,0.001446331,0.07513593,0.03092283,0.0007417157,0.02075445],"genre_scores_gemma":[0.9264237,0.004732593,0.007373132,0.002895722,0.0008372018,0.03145969,0.01237975,0.0001142427,0.01378394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01509457,"threshold_uncertainty_score":0.0504964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1758181269716558,"score_gpt":0.4757662955401537,"score_spread":0.2999481685684979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}