{"id":"W3135158970","doi":"10.1186/s13059-021-02301-6","title":"Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity","year":2021,"lang":"en","type":"article","venue":"Genome biology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute; National Institute of Mental Health; Translational Genomics Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; York University; National Institutes of Health; Rush University; Azrieli Foundation; Israel Science Foundation; Sidney Kimmel Foundation; National Cancer Institute; Illinois Department of Public Health; Howard Hughes Medical Institute","keywords":"Biology; Induced pluripotent stem cell; Phenotype; Disease; Genetic heterogeneity; Gene; Transcriptional regulation; Genetics; Neuroscience; Gene expression; Pathology; Embryonic stem cell; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002388043,0.0003934115,0.0002031076,0.0003415424,0.000118119,0.0002889192,0.0002273119,0.0002774196,0.0009330342],"category_scores_gemma":[0.0001307436,0.0001159354,0.0002157623,0.0001832505,0.0003264168,0.0001838975,0.0002188098,0.0005288248,0.0002544457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002451412,"about_ca_system_score_gemma":0.0001097149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001955013,"about_ca_topic_score_gemma":0.0004305415,"domain_scores_codex":[0.9998357,0.00002237126,0.00002700664,0.00004360853,0.00005436244,0.00001686187],"domain_scores_gemma":[0.999856,0.00003332565,0.00005267403,0.00002548223,0.00001340456,0.00001909649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000686752,0.00001843845,0.0003923998,0.00004351221,0.00001304468,0.00005845154,0.00001630788,0.0002236388,0.9976949,0.0002617603,0.00006057312,0.001148298],"study_design_scores_gemma":[0.00002445738,0.0003373761,0.009129573,0.00001984175,0.00005896238,0.0005379554,0.00004379189,0.001985229,0.9839298,0.0006021847,0.00332068,0.00001012166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667705,0.001817232,0.02562124,0.0001768066,0.00005776187,0.0001129494,0.003385461,0.000337232,0.001720888],"genre_scores_gemma":[0.9853525,0.00118557,0.007714226,0.00009629838,0.00001255208,0.000147852,0.003889071,0.00004912328,0.001552819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009330342,"threshold_uncertainty_score":0.003121257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411675391210338,"score_gpt":0.2208533657145096,"score_spread":0.1967366118024062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}