{"id":"W3135162074","doi":"10.1038/s41419-021-03526-w","title":"Impairment in inflammasome signaling by the chronic Pseudomonas aeruginosa isolates from cystic fibrosis patients results in an increase in inflammatory response","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Ottawa","funders":"Office of Extramural Research, National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; National Institutes of Health; Government of Canada; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Pseudomonas aeruginosa; Inflammasome; Cystic fibrosis; Microbiology; Virulence; Biology; Inflammation; Immunology; Chronic infection; Immune system; Cytokine; Programmed cell death; Bacteria; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017051,0.0003166313,0.0002860105,0.0001602499,0.0001920996,0.0003504027,0.00007743554,0.0003706194,0.001368668],"category_scores_gemma":[0.0002102182,0.000130956,0.00025265,0.0001360234,0.0002300318,0.0002147988,0.0003478823,0.0007421673,0.0003079793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001680828,"about_ca_system_score_gemma":0.0001927291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003595235,"about_ca_topic_score_gemma":0.0003593904,"domain_scores_codex":[0.9997279,0.00004458991,0.00002957321,0.00005327398,0.00006641337,0.00007827296],"domain_scores_gemma":[0.9998454,0.00001908303,0.00005641593,0.00001325828,0.00001987166,0.00004597128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004310464,0.00005258933,0.00294061,0.00005790473,0.000008489867,0.0002618137,0.00006213444,0.00001599575,0.9945614,0.00003389854,0.00006233297,0.001511733],"study_design_scores_gemma":[0.0001301286,0.004556308,0.3318121,0.00006977779,0.00007415393,0.006308733,0.0006146506,0.0008136061,0.6506997,0.0002884936,0.004604568,0.00002776615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971108,0.001613386,0.0005298411,0.0001206824,0.00001563446,0.00001969688,0.0002162349,0.00001176592,0.0003618154],"genre_scores_gemma":[0.9980029,0.0006132258,0.0004887589,0.00008146316,0.00001136919,0.0000382558,0.0002562307,0.000003459034,0.00050417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368668,"threshold_uncertainty_score":0.00457865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004272756269300803,"score_gpt":0.2017243294844405,"score_spread":0.1974515732151397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}